node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BACE2 | TMEM27 | ENSP00000332979 | ENSP00000369699 | Beta-secretase 2; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 | Collectrin; Regulator of SNARE complex function. Stimulator of beta cell replication; Belongs to the TMEM27 family | 0.841 |
CTSE | INS | ENSP00000350911 | ENSP00000380432 | Cathepsin E; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain; Cathepsins | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver | 0.460 |
CTSE | TMEM27 | ENSP00000350911 | ENSP00000369699 | Cathepsin E; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain; Cathepsins | Collectrin; Regulator of SNARE complex function. Stimulator of beta cell replication; Belongs to the TMEM27 family | 0.579 |
FAM132A | TMEM27 | ENSP00000329137 | ENSP00000369699 | Adipolin; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue | Collectrin; Regulator of SNARE complex function. Stimulator of beta cell replication; Belongs to the TMEM27 family | 0.621 |
INS | CTSE | ENSP00000380432 | ENSP00000350911 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver | Cathepsin E; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain; Cathepsins | 0.460 |
INS | SLC1A7 | ENSP00000380432 | ENSP00000478639 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver | Amino acid transporter; Solute carrier family 1 member 7 | 0.491 |
INS | SLC5A2 | ENSP00000380432 | ENSP00000327943 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver | Sodium/glucose cotransporter 2; Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1-1; Solute carriers | 0.873 |
INS | TMEM27 | ENSP00000380432 | ENSP00000369699 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver | Collectrin; Regulator of SNARE complex function. Stimulator of beta cell replication; Belongs to the TMEM27 family | 0.937 |
MEP1B | TMEM27 | ENSP00000269202 | ENSP00000369699 | Meprin A subunit beta; Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1’ position. Known substrates include- FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components; Astacins | Collectrin; Regulator of SNARE complex function. Stimulator of beta cell replication; Belongs to the TMEM27 family | 0.535 |
SLC1A7 | INS | ENSP00000478639 | ENSP00000380432 | Amino acid transporter; Solute carrier family 1 member 7 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver | 0.491 |
SLC1A7 | SLC6A18 | ENSP00000478639 | ENSP00000323549 | Amino acid transporter; Solute carrier family 1 member 7 | Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily | 0.810 |
SLC1A7 | SLC6A19 | ENSP00000478639 | ENSP00000305302 | Amino acid transporter; Solute carrier family 1 member 7 | Sodium-dependent neutral amino acid transporter B(0)AT1; Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride- independent; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily | 0.817 |
SLC1A7 | TMEM27 | ENSP00000478639 | ENSP00000369699 | Amino acid transporter; Solute carrier family 1 member 7 | Collectrin; Regulator of SNARE complex function. Stimulator of beta cell replication; Belongs to the TMEM27 family | 0.568 |
SLC5A2 | INS | ENSP00000327943 | ENSP00000380432 | Sodium/glucose cotransporter 2; Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1-1; Solute carriers | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver | 0.873 |
SLC5A2 | SLC6A18 | ENSP00000327943 | ENSP00000323549 | Sodium/glucose cotransporter 2; Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1-1; Solute carriers | Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily | 0.722 |
SLC5A2 | SLC6A19 | ENSP00000327943 | ENSP00000305302 | Sodium/glucose cotransporter 2; Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1-1; Solute carriers | Sodium-dependent neutral amino acid transporter B(0)AT1; Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride- independent; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily | 0.531 |
SLC5A2 | TMEM27 | ENSP00000327943 | ENSP00000369699 | Sodium/glucose cotransporter 2; Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1-1; Solute carriers | Collectrin; Regulator of SNARE complex function. Stimulator of beta cell replication; Belongs to the TMEM27 family | 0.543 |
SLC6A18 | SLC1A7 | ENSP00000323549 | ENSP00000478639 | Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily | Amino acid transporter; Solute carrier family 1 member 7 | 0.810 |
SLC6A18 | SLC5A2 | ENSP00000323549 | ENSP00000327943 | Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily | Sodium/glucose cotransporter 2; Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1-1; Solute carriers | 0.722 |
SLC6A18 | TMEM27 | ENSP00000323549 | ENSP00000369699 | Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily | Collectrin; Regulator of SNARE complex function. Stimulator of beta cell replication; Belongs to the TMEM27 family | 0.657 |