• Version:
  • 11.0 [archived version]
STRINGSTRING
PCIF1 PCIF1 STON2 STON2 FBXO25 FBXO25 ERICH1 ERICH1 RSBN1L RSBN1L SLC22A23 SLC22A23 PRPF4B PRPF4B PXDC1 PXDC1 ZMIZ1 ZMIZ1 IQCG IQCG C12orf60 C12orf60
"PXDC1" - PX domain containing 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PXDC1PX domain containing 1 (231 aa)    
Predicted Functional Partners:
SLC22A23
Solute carrier family 22 member 23 (686 aa)
           
  0.854
PRPF4B
Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF (1007 aa)
           
  0.794
RSBN1L
Round spermatid basic protein 1 like (846 aa)
           
  0.736
ERICH1
Glutamate-rich protein 1; Glutamate rich 1 (443 aa)
           
  0.698
PCIF1
Phosphorylated CTD-interacting factor 1; May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit; Protein phosphatase 1 regulatory subunits (704 aa)
           
  0.669
STON2
Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family (920 aa)
           
  0.596
C12orf60
Uncharacterized protein C12orf60; Chromosome 12 open reading frame 60 (245 aa)
           
  0.570
FBXO25
F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity); F-boxes other (367 aa)
           
  0.569
ZMIZ1
Zinc finger MIZ domain-containing protein 1; Acts as transcriptional coactivator. Increases ligand- dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity); Zinc fingers MIZ-type (1067 aa)
           
  0.551
IQCG
IQ domain-containing protein G; Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin- dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (Probable). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility (443 aa)
           
  0.522
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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