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STRINGSTRING
LRRC9 LRRC9 CDRT4 CDRT4 IFNW1 IFNW1 FAM160B1 FAM160B1 FOCAD FOCAD LETMD1 LETMD1 TEX35 TEX35 PTPLAD2 PTPLAD2 DHX32 DHX32 STK19 STK19 VCL VCL
"FOCAD" - Focadhesin in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
FOCADFocadhesin; Potential tumor suppressor in gliomas; Armadillo-like helical domain containing (1801 aa)    
Predicted Functional Partners:
PTPLAD2
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4; Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (232 aa)
      
   
  0.545
CDRT4
CMT1A duplicated region transcript 4 (152 aa)
            
  0.531
TEX35
Testis-expressed protein 35; Testis expressed 35 (233 aa)
            
  0.528
FAM160B1
Protein FAM160B1; Family with sequence similarity 160 member B1; Armadillo-like helical domain containing (765 aa)
            
  0.486
LRRC9
Leucine-rich repeat-containing protein 9; Leucine rich repeat containing 9 (1453 aa)
            
  0.473
VCL
Vinculin; Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family (1134 aa)
        
 
  0.456
STK19
Serine/threonine-protein kinase 19; Seems to be a protein kinase. In vitro it can phosphorylate casein-alpha on serine and threonine residues and histones on serine residues (368 aa)
            
  0.432
IFNW1
Interferon omega 1; Interferons (195 aa)
      
   
  0.428
LETMD1
LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers (373 aa)
            
  0.424
DHX32
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32; DEAH-box helicase 32; Belongs to the DEAD box helicase family. DEAH subfamily (743 aa)
      
   
  0.423
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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