• Version:
  • 11.0 [archived version]
STRINGSTRING
ARHGAP23 ARHGAP23 AGFG2 AGFG2 SEPT10 SEPT10 ARHGAP21 ARHGAP21 SNX16 SNX16 CCDC85C CCDC85C PKP4 PKP4 CCDC184 CCDC184 SOBP SOBP ARVCF ARVCF C14orf180 C14orf180
"CCDC85C" - Coiled-coil domain-containing protein 85C in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CCDC85CCoiled-coil domain-containing protein 85C; May play an important role in cortical development, especially in the maintenance of radial glia (419 aa)    
Predicted Functional Partners:
ARHGAP23
Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state; PDZ domain containing (1491 aa)
     
 
  0.856
ARHGAP21
Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions; PDZ domain containing (1958 aa)
     
 
  0.836
ARVCF
Armadillo repeat protein deleted in velo-cardio-facial syndrome; Involved in protein-protein interactions at adherens junctions; Belongs to the beta-catenin family (962 aa)
     
 
  0.738
C14orf180
Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 (177 aa)
           
  0.707
SOBP
Sine oculis-binding protein homolog; Implicated in development of the cochlea (873 aa)
     
   
  0.700
CCDC184
Coiled-coil domain containing 184 (194 aa)
           
  0.617
AGFG2
Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2; ArfGAPs (481 aa)
           
  0.604
SNX16
Sorting nexin-16; May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm; Belongs to the sorting nexin family (344 aa)
           
  0.582
PKP4
Plakophilin-4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques; Armadillo repeat containing (1192 aa)
       
 
  0.548
SEPT10
Septin-10; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Septin GTPase family (454 aa)
           
  0.545
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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