node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IFNA16 | IFNA2 | ENSP00000369564 | ENSP00000369554 | Interferon alpha-16; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | 0.908 |
IFNA16 | IFNA4 | ENSP00000369564 | ENSP00000412897 | Interferon alpha-16; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Interferon alpha-4; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family | 0.911 |
IFNA16 | IFNA6 | ENSP00000369564 | ENSP00000369558 | Interferon alpha-16; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Interferon alpha-6; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | 0.910 |
IFNA16 | IFNA7 | ENSP00000369564 | ENSP00000239347 | Interferon alpha-16; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Interferon alpha-7; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | 0.919 |
IFNA16 | IFNA8 | ENSP00000369564 | ENSP00000369553 | Interferon alpha-16; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Interferon alpha-8; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | 0.907 |
IFNA16 | IFNAR1 | ENSP00000369564 | ENSP00000270139 | Interferon alpha-16; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity) | 0.918 |
IFNA16 | IFNAR2 | ENSP00000369564 | ENSP00000343957 | Interferon alpha-16; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Interferon alpha/beta receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity | 0.905 |
IFNA16 | IFNB1 | ENSP00000369564 | ENSP00000369581 | Interferon alpha-16; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Interferon beta; Has antiviral, antibacterial and anticancer activities; Belongs to the alpha/beta interferon family | 0.908 |
IFNA16 | IRF3 | ENSP00000369564 | ENSP00000471896 | Interferon alpha-16; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive [...] | 0.901 |
IFNA16 | IRF7 | ENSP00000369564 | ENSP00000380697 | Interferon alpha-16; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent [...] | 0.907 |
IFNA2 | IFNA16 | ENSP00000369554 | ENSP00000369564 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Interferon alpha-16; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | 0.908 |
IFNA2 | IFNA4 | ENSP00000369554 | ENSP00000412897 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Interferon alpha-4; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family | 0.982 |
IFNA2 | IFNA6 | ENSP00000369554 | ENSP00000369558 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Interferon alpha-6; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | 0.914 |
IFNA2 | IFNA7 | ENSP00000369554 | ENSP00000239347 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Interferon alpha-7; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | 0.906 |
IFNA2 | IFNA8 | ENSP00000369554 | ENSP00000369553 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Interferon alpha-8; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | 0.908 |
IFNA2 | IFNAR1 | ENSP00000369554 | ENSP00000270139 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity) | 0.994 |
IFNA2 | IFNAR2 | ENSP00000369554 | ENSP00000343957 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Interferon alpha/beta receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity | 0.993 |
IFNA2 | IFNB1 | ENSP00000369554 | ENSP00000369581 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Interferon beta; Has antiviral, antibacterial and anticancer activities; Belongs to the alpha/beta interferon family | 0.916 |
IFNA2 | IRF3 | ENSP00000369554 | ENSP00000471896 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive [...] | 0.956 |
IFNA2 | IRF7 | ENSP00000369554 | ENSP00000380697 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent [...] | 0.978 |