node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAED1 | ANKRD16 | ENSP00000364382 | ENSP00000369436 | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | 0.543 |
ANKRD16 | AAED1 | ENSP00000369436 | ENSP00000364382 | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | 0.543 |
ANKRD16 | ARL4A | ENSP00000369436 | ENSP00000379898 | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | ADP-ribosylation factor-like protein 4A; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form; ARF GTPase family | 0.599 |
ANKRD16 | DOK5 | ENSP00000369436 | ENSP00000262593 | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | Docking protein 5; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation | 0.518 |
ANKRD16 | FBXO18 | ENSP00000369436 | ENSP00000369335 | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | F-box DNA helicase 1; 3’-5’ DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination- promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress- together with M [...] | 0.711 |
ANKRD16 | GUCY1B3 | ENSP00000369436 | ENSP00000264424 | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family | 0.550 |
ANKRD16 | ITIH5 | ENSP00000369436 | ENSP00000380333 | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor | 0.562 |
ANKRD16 | NSMCE4A | ENSP00000369436 | ENSP00000358019 | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | Non-structural maintenance of chromosomes element 4 homolog A; Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies ( [...] | 0.704 |
ANKRD16 | OR51V1 | ENSP00000369436 | ENSP00000321729 | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | Olfactory receptor 51V1; Odorant receptor; Olfactory receptors, family 51 | 0.770 |
ANKRD16 | RREB1 | ENSP00000369436 | ENSP00000369270 | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | Ras-responsive element-binding protein 1; Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1; Zinc fingers C2H2-type | 0.514 |
ANKRD16 | TMEM14C | ENSP00000369436 | ENSP00000444561 | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | Transmembrane protein 14C; Required for normal heme biosynthesis | 0.533 |
ARL4A | ANKRD16 | ENSP00000379898 | ENSP00000369436 | ADP-ribosylation factor-like protein 4A; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form; ARF GTPase family | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | 0.599 |
ARL4A | NSMCE4A | ENSP00000379898 | ENSP00000358019 | ADP-ribosylation factor-like protein 4A; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form; ARF GTPase family | Non-structural maintenance of chromosomes element 4 homolog A; Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies ( [...] | 0.562 |
DOK5 | ANKRD16 | ENSP00000262593 | ENSP00000369436 | Docking protein 5; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | 0.518 |
DOK5 | OR51V1 | ENSP00000262593 | ENSP00000321729 | Docking protein 5; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation | Olfactory receptor 51V1; Odorant receptor; Olfactory receptors, family 51 | 0.651 |
FBXO18 | ANKRD16 | ENSP00000369335 | ENSP00000369436 | F-box DNA helicase 1; 3’-5’ DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination- promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress- together with M [...] | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | 0.711 |
FBXO18 | ITIH5 | ENSP00000369335 | ENSP00000380333 | F-box DNA helicase 1; 3’-5’ DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination- promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress- together with M [...] | Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor | 0.402 |
GUCY1B3 | ANKRD16 | ENSP00000264424 | ENSP00000369436 | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | 0.550 |
GUCY1B3 | OR51V1 | ENSP00000264424 | ENSP00000321729 | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family | Olfactory receptor 51V1; Odorant receptor; Olfactory receptors, family 51 | 0.580 |
ITIH5 | ANKRD16 | ENSP00000380333 | ENSP00000369436 | Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | 0.562 |