• Version:
  • 11.0 [archived version]
STRINGSTRING
TRAF7 TRAF7 HIPK2 HIPK2 EFHC2 EFHC2 CDKL5 CDKL5 KNCN KNCN NHS NHS RAI2 RAI2 MAP4K5 MAP4K5 GCNT2 GCNT2 HMGN4 HMGN4 HMGN2 HMGN2
"NHS" - Nance-Horan syndrome protein in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
NHSNance-Horan syndrome protein; May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development; Belongs to the NHS family (1630 aa)    
Predicted Functional Partners:
RAI2
Retinoic acid induced 2 (530 aa)
     
   
  0.941
GCNT2
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells; Belongs to the glycosyltransferase 14 family (402 aa)
           
  0.757
CDKL5
Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated (1030 aa)
     
   
  0.749
MAP4K5
Mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway; Mitogen-activated protein kinase kinase kinase kinases (846 aa)
           
  0.568
EFHC2
EF-hand domain-containing family member C2; EF-hand domain containing 2 (749 aa)
     
        0.561
HMGN4
High mobility group nucleosomal binding domain 4; Belongs to the HMGN family (90 aa)
           
  0.522
HMGN2
Non-histone chromosomal protein HMG-17; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity); Canonical high mobility group (90 aa)
           
  0.512
TRAF7
E3 ubiquitin-protein ligase TRAF7; E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed; Belongs to the WD repeat TRAF7 family (670 aa)
           
  0.490
HIPK2
Homeodomain-interacting protein kinase 2; Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect [...] (1198 aa)
           
  0.476
KNCN
Kinocilin (101 aa)
           
  0.473
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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