• Version:
  • 11.0 [archived version]
STRINGSTRING
SCML2 SCML2 RAI2 RAI2 BANP BANP BEND4 BEND4 BEND3 BEND3 WIPF3 WIPF3 BEND2 BEND2 GPR82 GPR82 PLCXD1 PLCXD1 EFHC2 EFHC2 GTPBP6 GTPBP6
"BEND2" - BEN domain containing 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BEND2BEN domain containing 2 (799 aa)    
Predicted Functional Partners:
BEND4
BEN domain containing 4 (534 aa)
           
  0.773
BANP
Protein BANP; Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 ’Ser-15’ phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity); Belongs to the BANP/SMAR1 family (519 aa)
           
  0.663
WIPF3
WAS/WASL-interacting protein family member 3; May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity); Belongs to the verprolin family (483 aa)
           
  0.622
BEND3
BEN domain-containing protein 3; Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination. Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities; BEN domain containing (828 aa)
           
  0.471
EFHC2
EF-hand domain-containing family member C2; EF-hand domain containing 2 (749 aa)
           
  0.446
RAI2
Retinoic acid induced 2 (530 aa)
           
  0.440
SCML2
Sex comb on midleg-like protein 2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity); MBT domain containing (700 aa)
           
  0.440
PLCXD1
PI-PLC X domain-containing protein 1; Phosphatidylinositol specific phospholipase C X domain containing 1; Pseudoautosomal region 1 (323 aa)
           
  0.420
GTPBP6
Putative GTP-binding protein 6; Pseudoautosomal region 1 (516 aa)
           
  0.420
GPR82
Probable G-protein coupled receptor 82; Orphan receptor; G protein-coupled receptors, Class A orphans (336 aa)
     
   
  0.418
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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