| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AP5S1 | LETM2 | ENSP00000481750 | ENSP00000369291 | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair | LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2 | 0.564 |
| AP5S1 | PRND | ENSP00000481750 | ENSP00000306900 | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+); Belongs to the prion family | 0.656 |
| AP5S1 | PROM2 | ENSP00000481750 | ENSP00000318270 | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair | Prominin-2; Prominin 2 | 0.499 |
| AP5S1 | SPRN | ENSP00000481750 | ENSP00000433712 | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity) | 0.748 |
| DDHD2 | GOT1L1 | ENSP00000380352 | ENSP00000303077 | Phospholipase DDHD2; Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4- phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane; Sterile alpha motif domain containing | Putative aspartate aminotransferase, cytoplasmic 2; Glutamic-oxaloacetic transaminase 1 like 1 | 0.400 |
| DDHD2 | LETM2 | ENSP00000380352 | ENSP00000369291 | Phospholipase DDHD2; Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4- phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane; Sterile alpha motif domain containing | LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2 | 0.560 |
| DDHD2 | PPAPDC1B | ENSP00000380352 | ENSP00000392553 | Phospholipase DDHD2; Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4- phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane; Sterile alpha motif domain containing | Phospholipid phosphatase 5; Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma | 0.700 |
| DDHD2 | TM2D2 | ENSP00000380352 | ENSP00000416050 | Phospholipase DDHD2; Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4- phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane; Sterile alpha motif domain containing | TM2 domain containing 2 | 0.617 |
| GOT1L1 | DDHD2 | ENSP00000303077 | ENSP00000380352 | Putative aspartate aminotransferase, cytoplasmic 2; Glutamic-oxaloacetic transaminase 1 like 1 | Phospholipase DDHD2; Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4- phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane; Sterile alpha motif domain containing | 0.400 |
| GOT1L1 | LETM2 | ENSP00000303077 | ENSP00000369291 | Putative aspartate aminotransferase, cytoplasmic 2; Glutamic-oxaloacetic transaminase 1 like 1 | LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2 | 0.594 |
| GOT1L1 | PPAPDC1B | ENSP00000303077 | ENSP00000392553 | Putative aspartate aminotransferase, cytoplasmic 2; Glutamic-oxaloacetic transaminase 1 like 1 | Phospholipid phosphatase 5; Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma | 0.441 |
| GOT1L1 | TM2D2 | ENSP00000303077 | ENSP00000416050 | Putative aspartate aminotransferase, cytoplasmic 2; Glutamic-oxaloacetic transaminase 1 like 1 | TM2 domain containing 2 | 0.473 |
| LETM2 | AP5S1 | ENSP00000369291 | ENSP00000481750 | LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2 | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair | 0.564 |
| LETM2 | DDHD2 | ENSP00000369291 | ENSP00000380352 | LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2 | Phospholipase DDHD2; Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4- phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane; Sterile alpha motif domain containing | 0.560 |
| LETM2 | GOT1L1 | ENSP00000369291 | ENSP00000303077 | LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2 | Putative aspartate aminotransferase, cytoplasmic 2; Glutamic-oxaloacetic transaminase 1 like 1 | 0.594 |
| LETM2 | PAOX | ENSP00000369291 | ENSP00000278060 | LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2 | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase; Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity- N(1)-acetylspermine = N(1)- acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs; Belongs to the flavin m [...] | 0.635 |
| LETM2 | PPAPDC1B | ENSP00000369291 | ENSP00000392553 | LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2 | Phospholipid phosphatase 5; Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma | 0.605 |
| LETM2 | PRND | ENSP00000369291 | ENSP00000306900 | LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2 | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+); Belongs to the prion family | 0.617 |
| LETM2 | PROM2 | ENSP00000369291 | ENSP00000318270 | LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2 | Prominin-2; Prominin 2 | 0.705 |
| LETM2 | SPRN | ENSP00000369291 | ENSP00000433712 | LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2 | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity) | 0.637 |
