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  • 11.0 [archived version]
STRINGSTRING
RNF219 RNF219 TPST1 TPST1 SLC35A5 SLC35A5 SLC35B3 SLC35B3 SLC35D1 SLC35D1 SLC35C1 SLC35C1 NIPAL1 NIPAL1 SLC35A1 SLC35A1 SLC35C2 SLC35C2 SLC30A1 SLC30A1 TMEM144 TMEM144
"SLC35B3" - Adenosine 3'-phospho 5'-phosphosulfate transporter 2 in Homo sapiens
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SLC35B3Adenosine 3’-phospho 5’-phosphosulfate transporter 2; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon; Solute carriers (401 aa)    
Predicted Functional Partners:
SLC35C2
Solute carrier family 35 member C2; May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells; Solute carriers (394 aa)
           
  0.832
SLC35C1
GDP-fucose transporter 1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen; Belongs to the TPT transporter family. SLC35C subfamily (364 aa)
     
   
  0.807
TMEM144
Transmembrane protein 144; Belongs to the TMEM144 family (345 aa)
           
  0.781
SLC35A1
CMP-sialic acid transporter; Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function; Belongs to the nucleotide-sugar transporter family. SLC35A subfamily (337 aa)
     
   
  0.736
SLC35D1
UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; Transports both UDP-glucuronic acid (UDP-GlcA) and UDP- N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen. Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity); Solute carriers (355 aa)
           
  0.729
NIPAL1
Magnesium transporter NIPA3; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity) (410 aa)
     
   
  0.722
TPST1
Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family (370 aa)
     
   
  0.685
SLC35A5
Probable UDP-sugar transporter protein SLC35A5; Solute carrier family 35 member A5 (424 aa)
     
   
  0.672
RNF219
Ring finger protein 219 (726 aa)
           
  0.667
SLC30A1
Zinc transporter 1; May be involved in zinc transport out of the cell; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily (507 aa)
     
 
  0.629
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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