node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFAP1L1 | CCDC112 | ENSP00000296721 | ENSP00000368931 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | Coiled-coil domain containing 112 | 0.451 |
AFAP1L1 | COMMD10 | ENSP00000296721 | ENSP00000274458 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | COMM domain-containing protein 10; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B | 0.435 |
AFAP1L1 | SPINK14 | ENSP00000296721 | ENSP00000349459 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | Serine protease inhibitor Kazal-type 14; May be a serine protease inhibitor; Serine peptidase inhibitors, Kazal type | 0.426 |
AFAP1L1 | ZNF474 | ENSP00000296721 | ENSP00000296600 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | Zinc finger protein 474; Zinc fingers C2H2-type | 0.410 |
CCDC112 | AFAP1L1 | ENSP00000368931 | ENSP00000296721 | Coiled-coil domain containing 112 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | 0.451 |
CCDC112 | CCDC14 | ENSP00000368931 | ENSP00000420180 | Coiled-coil domain containing 112 | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization | 0.429 |
CCDC112 | COMMD10 | ENSP00000368931 | ENSP00000274458 | Coiled-coil domain containing 112 | COMM domain-containing protein 10; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B | 0.476 |
CCDC112 | ESYT1 | ENSP00000368931 | ENSP00000267113 | Coiled-coil domain containing 112 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family | 0.732 |
CCDC112 | MAP7D3 | ENSP00000368931 | ENSP00000318086 | Coiled-coil domain containing 112 | MAP7 domain-containing protein 3; Promotes the assembly and stability of microtubules | 0.456 |
CCDC112 | MCC | ENSP00000368931 | ENSP00000386227 | Coiled-coil domain containing 112 | Colorectal mutant cancer protein; Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and n [...] | 0.437 |
CCDC112 | MCOLN3 | ENSP00000368931 | ENSP00000359621 | Coiled-coil domain containing 112 | Mucolipin-3; Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle grow [...] | 0.687 |
CCDC112 | SPINK14 | ENSP00000368931 | ENSP00000349459 | Coiled-coil domain containing 112 | Serine protease inhibitor Kazal-type 14; May be a serine protease inhibitor; Serine peptidase inhibitors, Kazal type | 0.503 |
CCDC112 | TEX9 | ENSP00000368931 | ENSP00000342169 | Coiled-coil domain containing 112 | Testis-expressed protein 9; Testis expressed 9 | 0.757 |
CCDC112 | ZNF474 | ENSP00000368931 | ENSP00000296600 | Coiled-coil domain containing 112 | Zinc finger protein 474; Zinc fingers C2H2-type | 0.453 |
CCDC14 | CCDC112 | ENSP00000420180 | ENSP00000368931 | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization | Coiled-coil domain containing 112 | 0.429 |
CCDC14 | MAP7D3 | ENSP00000420180 | ENSP00000318086 | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization | MAP7 domain-containing protein 3; Promotes the assembly and stability of microtubules | 0.483 |
COMMD10 | AFAP1L1 | ENSP00000274458 | ENSP00000296721 | COMM domain-containing protein 10; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | 0.435 |
COMMD10 | CCDC112 | ENSP00000274458 | ENSP00000368931 | COMM domain-containing protein 10; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B | Coiled-coil domain containing 112 | 0.476 |
COMMD10 | SPINK14 | ENSP00000274458 | ENSP00000349459 | COMM domain-containing protein 10; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B | Serine protease inhibitor Kazal-type 14; May be a serine protease inhibitor; Serine peptidase inhibitors, Kazal type | 0.410 |
COMMD10 | ZNF474 | ENSP00000274458 | ENSP00000296600 | COMM domain-containing protein 10; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B | Zinc finger protein 474; Zinc fingers C2H2-type | 0.405 |