• Version:
  • 11.0 [archived version]
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CCDC14 CCDC14 MAP7D3 MAP7D3 MCC MCC TEX9 TEX9 MCOLN3 MCOLN3 CCDC112 CCDC112 ESYT1 ESYT1 SPINK14 SPINK14 AFAP1L1 AFAP1L1 ZNF474 ZNF474 COMMD10 COMMD10
"CCDC112" - Coiled-coil domain containing 112 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
CCDC112Coiled-coil domain containing 112 (529 aa)    
Predicted Functional Partners:
TEX9
Testis-expressed protein 9; Testis expressed 9 (391 aa)
       
 
  0.757
ESYT1
Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family (1114 aa)
           
  0.732
MCOLN3
Mucolipin-3; Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle grow [...] (553 aa)
           
  0.687
SPINK14
Serine protease inhibitor Kazal-type 14; May be a serine protease inhibitor; Serine peptidase inhibitors, Kazal type (97 aa)
           
  0.503
COMMD10
COMM domain-containing protein 10; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B (202 aa)
     
   
  0.476
MAP7D3
MAP7 domain-containing protein 3; Promotes the assembly and stability of microtubules (876 aa)
           
  0.456
ZNF474
Zinc finger protein 474; Zinc fingers C2H2-type (364 aa)
           
  0.453
AFAP1L1
Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing (768 aa)
           
  0.451
MCC
Colorectal mutant cancer protein; Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and n [...] (1019 aa)
       
 
  0.437
CCDC14
Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization (912 aa)
           
  0.429
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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