PAK1IP1 protein (human) - STRING database

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PAK1IP1

P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly; WD repeat domain containing (392 aa)

Predicted Functional Partners:

WDR12

0.981

RSL24D1

0.979

NIP7

0.978

RPF2

0.974

NOP2

0.968

DDX55

0.961

MAK16

0.959

GNL2

0.957

GTPBP4

0.955

BOP1

0.951

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BOP1	DDX55	ENSP00000455106	ENSP00000238146	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases	0.968
BOP1	GNL2	ENSP00000455106	ENSP00000362153	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation	0.944
BOP1	GTPBP4	ENSP00000455106	ENSP00000354040	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily	0.986
BOP1	MAK16	ENSP00000455106	ENSP00000353246	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Protein MAK16 homolog; RNA binding motif containing	0.985
BOP1	NIP7	ENSP00000455106	ENSP00000254940	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family	0.988
BOP1	NOP2	ENSP00000455106	ENSP00000371858	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family	0.997
BOP1	PAK1IP1	ENSP00000455106	ENSP00000368887	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly; WD repeat domain containing	0.951
BOP1	RPF2	ENSP00000455106	ENSP00000402338	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus	0.971
BOP1	RSL24D1	ENSP00000455106	ENSP00000260443	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity); Belongs to the eukaryotic ribosomal protein eL24 family	0.987
BOP1	WDR12	ENSP00000455106	ENSP00000261015	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; WD repeat domain containing	0.999
DDX55	BOP1	ENSP00000238146	ENSP00000455106	ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	0.968
DDX55	GNL2	ENSP00000238146	ENSP00000362153	ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation	0.933
DDX55	GTPBP4	ENSP00000238146	ENSP00000354040	ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily	0.982
DDX55	MAK16	ENSP00000238146	ENSP00000353246	ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases	Protein MAK16 homolog; RNA binding motif containing	0.938
DDX55	NIP7	ENSP00000238146	ENSP00000254940	ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family	0.972
DDX55	NOP2	ENSP00000238146	ENSP00000371858	ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family	0.947
DDX55	PAK1IP1	ENSP00000238146	ENSP00000368887	ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases	P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly; WD repeat domain containing	0.961
DDX55	RPF2	ENSP00000238146	ENSP00000402338	ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus	0.975
DDX55	RSL24D1	ENSP00000238146	ENSP00000260443	ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases	Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity); Belongs to the eukaryotic ribosomal protein eL24 family	0.961
DDX55	WDR12	ENSP00000238146	ENSP00000261015	ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; WD repeat domain containing	0.963

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