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  • 11.0 [archived version]
STRINGSTRING
LYZ LYZ ARMC8 ARMC8 YPEL5 YPEL5 ALDOA ALDOA IDH1 IDH1 B2M B2M ALDOC ALDOC CTSH CTSH CTSS CTSS GOLGA7 GOLGA7 LRG1 LRG1
"YPEL5" - Protein yippee-like 5 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
YPEL5Protein yippee-like 5; Yippee like family; Belongs to the yippee family (121 aa)    
Predicted Functional Partners:
ARMC8
Armadillo repeat containing 8 (659 aa)
      
  0.966
CTSH
Pro-cathepsin H; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family (335 aa)
      
 
  0.909
LRG1
Leucine rich alpha-2-glycoprotein 1 (347 aa)
        
    0.908
ALDOA
Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity); Belongs to the class I fructose-bisphosphate aldolase family (418 aa)
          
  0.906
LYZ
Lysozyme C; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents; Lysozymes, c-type (148 aa)
          
  0.904
GOLGA7
Golgin subfamily A member 7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (137 aa)
      
 
    0.904
B2M
Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation; Belongs to the beta-2-microglobulin family (119 aa)
      
 
    0.902
IDH1
Isocitrate dehydrogenase 1, cytosolic (414 aa)
      
 
    0.902
ALDOC
Aldolase, fructose-bisphosphate C (364 aa)
          
  0.901
CTSS
Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N; Cathepsins (331 aa)
      
 
    0.901
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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