| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CLTC | TOM1L2 | ENSP00000479606 | ENSP00000368818 | Clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter- microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation; Belongs to the clathrin heavy chain [...] | TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | 0.629 |
| CUEDC1 | TOM1L2 | ENSP00000462717 | ENSP00000368818 | CUE domain containing 1 | TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | 0.665 |
| RCN1 | SULT1A1 | ENSP00000054950 | ENSP00000378972 | Reticulocalbin-1; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; EF-hand domain containing | Sulfotransferase 1A1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk; Sulfotransferases, cytosolic | 0.411 |
| RCN1 | TOM1L2 | ENSP00000054950 | ENSP00000368818 | Reticulocalbin-1; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; EF-hand domain containing | TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | 0.771 |
| S100A4 | SRXN1 | ENSP00000357705 | ENSP00000371388 | S100 calcium binding protein A4; EF-hand domain containing | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase; Belongs to the sulfiredoxin family | 0.471 |
| S100A4 | TOM1L2 | ENSP00000357705 | ENSP00000368818 | S100 calcium binding protein A4; EF-hand domain containing | TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | 0.780 |
| SIN3A | TOM1L2 | ENSP00000378402 | ENSP00000368818 | Paired amphipathic helix protein Sin3a; Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates wit [...] | TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | 0.796 |
| SRXN1 | S100A4 | ENSP00000371388 | ENSP00000357705 | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase; Belongs to the sulfiredoxin family | S100 calcium binding protein A4; EF-hand domain containing | 0.471 |
| SRXN1 | SULT1A1 | ENSP00000371388 | ENSP00000378972 | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase; Belongs to the sulfiredoxin family | Sulfotransferase 1A1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk; Sulfotransferases, cytosolic | 0.817 |
| SRXN1 | TOM1L2 | ENSP00000371388 | ENSP00000368818 | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase; Belongs to the sulfiredoxin family | TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | 0.774 |
| SRXN1 | UBA2 | ENSP00000371388 | ENSP00000246548 | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase; Belongs to the sulfiredoxin family | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2; Ubiquitin like modifier activating enzymes | 0.825 |
| SULT1A1 | RCN1 | ENSP00000378972 | ENSP00000054950 | Sulfotransferase 1A1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk; Sulfotransferases, cytosolic | Reticulocalbin-1; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; EF-hand domain containing | 0.411 |
| SULT1A1 | SRXN1 | ENSP00000378972 | ENSP00000371388 | Sulfotransferase 1A1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk; Sulfotransferases, cytosolic | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase; Belongs to the sulfiredoxin family | 0.817 |
| SULT1A1 | TOM1L2 | ENSP00000378972 | ENSP00000368818 | Sulfotransferase 1A1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk; Sulfotransferases, cytosolic | TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | 0.799 |
| SULT1A1 | UBA2 | ENSP00000378972 | ENSP00000246548 | Sulfotransferase 1A1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk; Sulfotransferases, cytosolic | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2; Ubiquitin like modifier activating enzymes | 0.828 |
| TOLLIP | TOM1L2 | ENSP00000314733 | ENSP00000368818 | Toll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin- ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates; C2 domain containing | TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | 0.708 |
| TOM1L2 | CLTC | ENSP00000368818 | ENSP00000479606 | TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | Clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter- microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation; Belongs to the clathrin heavy chain [...] | 0.629 |
| TOM1L2 | CUEDC1 | ENSP00000368818 | ENSP00000462717 | TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | CUE domain containing 1 | 0.665 |
| TOM1L2 | RCN1 | ENSP00000368818 | ENSP00000054950 | TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | Reticulocalbin-1; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; EF-hand domain containing | 0.771 |
| TOM1L2 | S100A4 | ENSP00000368818 | ENSP00000357705 | TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | S100 calcium binding protein A4; EF-hand domain containing | 0.780 |
