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STRINGSTRING
HNRNPUL1 HNRNPUL1 SF3A2 SF3A2 HNRNPM HNRNPM RNPS1 RNPS1 BUB3 BUB3 CMTM1 CMTM1 CMTM4 CMTM4 CMTM6 CMTM6 CMTM3 CMTM3 CMTM8 CMTM8 CMTM7 CMTM7
"CMTM1" - CKLF like MARVEL transmembrane domain containing 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CMTM1CKLF like MARVEL transmembrane domain containing 1 (286 aa)    
Predicted Functional Partners:
CMTM3
CKLF like MARVEL transmembrane domain containing 3; Belongs to the chemokine-like factor family (182 aa)
            
  0.905
CMTM4
CKLF like MARVEL transmembrane domain containing 4 (234 aa)
            
  0.905
CMTM7
CKLF like MARVEL transmembrane domain containing 7; Belongs to the chemokine-like factor family (175 aa)
            
  0.800
BUB3
Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. T [...] (328 aa)
        
      0.764
HNRNPM
Heterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines (730 aa)
        
      0.764
SF3A2
Splicing factor 3A subunit 2; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex; Belongs to the SF3A2 family (464 aa)
      
      0.740
CMTM6
CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family (183 aa)
            
  0.576
HNRNPUL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1; Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand- stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro (856 aa)
        
      0.571
CMTM8
CKLF like MARVEL transmembrane domain containing 8; Belongs to the chemokine-like factor family (173 aa)
            
  0.564
RNPS1
RNA-binding protein with serine-rich domain 1; Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the E [...] (305 aa)
        
      0.530
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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