• Version:
  • 11.0 [archived version]
STRINGSTRING
MLIP MLIP ASB15 ASB15 KLHL30 KLHL30 SMPX SMPX LMOD2 LMOD2 PPP1R3A PPP1R3A TTN TTN KLHL34 KLHL34 MSS51 MSS51 BTBD7 BTBD7 KCTD2 KCTD2
"KLHL34" - Kelch-like protein 34 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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KLHL34Kelch-like protein 34; Kelch like family member 34; BTB domain containing (644 aa)    
Predicted Functional Partners:
SMPX
Small muscular protein; Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair; Deafness associated genes (88 aa)
     
   
  0.788
MSS51
Putative protein MSS51 homolog, mitochondrial; MSS51 mitochondrial translational activator; Zinc fingers MYND-type (460 aa)
     
   
  0.667
KCTD2
BTB/POZ domain-containing protein KCTD2; Potassium channel tetramerization domain containing 2 (263 aa)
           
  0.640
BTBD7
BTB/POZ domain-containing protein 7; Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E- cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity); BTB domain containing (1132 aa)
     
   
  0.631
PPP1R3A
Protein phosphatase 1 regulatory subunit 3A; Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity); Protein phosphatase 1 regulatory subunits (1122 aa)
     
   
  0.621
ASB15
Ankyrin repeat and SOCS box protein 15; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family (588 aa)
     
   
  0.619
MLIP
Muscular LMNA-interacting protein; Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD (993 aa)
     
   
  0.589
LMOD2
Leiomodin-2; Mediates nucleation of actin filaments and thereby promotes actin polymerization. Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (547 aa)
     
      0.587
KLHL30
Kelch-like protein 30; Kelch like family member 30; BTB domain containing (578 aa)
     
     
0.583
TTN
Titin; Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase; Fibronectin type III domain containing (35991 aa)
     
      0.581
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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