node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASB15 | KLHL30 | ENSP00000397655 | ENSP00000386389 | Ankyrin repeat and SOCS box protein 15; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family | Kelch-like protein 30; Kelch like family member 30; BTB domain containing | 0.510 |
ASB15 | KLHL34 | ENSP00000397655 | ENSP00000368813 | Ankyrin repeat and SOCS box protein 15; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family | Kelch-like protein 34; Kelch like family member 34; BTB domain containing | 0.619 |
ASB15 | LMOD2 | ENSP00000397655 | ENSP00000411932 | Ankyrin repeat and SOCS box protein 15; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family | Leiomodin-2; Mediates nucleation of actin filaments and thereby promotes actin polymerization. Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function | 0.572 |
ASB15 | MLIP | ENSP00000397655 | ENSP00000426290 | Ankyrin repeat and SOCS box protein 15; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family | Muscular LMNA-interacting protein; Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD | 0.521 |
ASB15 | PPP1R3A | ENSP00000397655 | ENSP00000284601 | Ankyrin repeat and SOCS box protein 15; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family | Protein phosphatase 1 regulatory subunit 3A; Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity); Protein phosphatase 1 regulatory subunits | 0.603 |
BTBD7 | KCTD2 | ENSP00000335615 | ENSP00000312814 | BTB/POZ domain-containing protein 7; Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E- cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity); BTB domain containing | BTB/POZ domain-containing protein KCTD2; Potassium channel tetramerization domain containing 2 | 0.507 |
BTBD7 | KLHL34 | ENSP00000335615 | ENSP00000368813 | BTB/POZ domain-containing protein 7; Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E- cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity); BTB domain containing | Kelch-like protein 34; Kelch like family member 34; BTB domain containing | 0.631 |
KCTD2 | BTBD7 | ENSP00000312814 | ENSP00000335615 | BTB/POZ domain-containing protein KCTD2; Potassium channel tetramerization domain containing 2 | BTB/POZ domain-containing protein 7; Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E- cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity); BTB domain containing | 0.507 |
KCTD2 | KLHL34 | ENSP00000312814 | ENSP00000368813 | BTB/POZ domain-containing protein KCTD2; Potassium channel tetramerization domain containing 2 | Kelch-like protein 34; Kelch like family member 34; BTB domain containing | 0.640 |
KLHL30 | ASB15 | ENSP00000386389 | ENSP00000397655 | Kelch-like protein 30; Kelch like family member 30; BTB domain containing | Ankyrin repeat and SOCS box protein 15; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family | 0.510 |
KLHL30 | KLHL34 | ENSP00000386389 | ENSP00000368813 | Kelch-like protein 30; Kelch like family member 30; BTB domain containing | Kelch-like protein 34; Kelch like family member 34; BTB domain containing | 0.583 |
KLHL30 | MLIP | ENSP00000386389 | ENSP00000426290 | Kelch-like protein 30; Kelch like family member 30; BTB domain containing | Muscular LMNA-interacting protein; Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD | 0.510 |
KLHL30 | PPP1R3A | ENSP00000386389 | ENSP00000284601 | Kelch-like protein 30; Kelch like family member 30; BTB domain containing | Protein phosphatase 1 regulatory subunit 3A; Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity); Protein phosphatase 1 regulatory subunits | 0.531 |
KLHL30 | SMPX | ENSP00000386389 | ENSP00000368808 | Kelch-like protein 30; Kelch like family member 30; BTB domain containing | Small muscular protein; Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair; Deafness associated genes | 0.640 |
KLHL30 | TTN | ENSP00000386389 | ENSP00000467141 | Kelch-like protein 30; Kelch like family member 30; BTB domain containing | Titin; Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase; Fibronectin type III domain containing | 0.433 |
KLHL34 | ASB15 | ENSP00000368813 | ENSP00000397655 | Kelch-like protein 34; Kelch like family member 34; BTB domain containing | Ankyrin repeat and SOCS box protein 15; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family | 0.619 |
KLHL34 | BTBD7 | ENSP00000368813 | ENSP00000335615 | Kelch-like protein 34; Kelch like family member 34; BTB domain containing | BTB/POZ domain-containing protein 7; Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E- cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity); BTB domain containing | 0.631 |
KLHL34 | KCTD2 | ENSP00000368813 | ENSP00000312814 | Kelch-like protein 34; Kelch like family member 34; BTB domain containing | BTB/POZ domain-containing protein KCTD2; Potassium channel tetramerization domain containing 2 | 0.640 |
KLHL34 | KLHL30 | ENSP00000368813 | ENSP00000386389 | Kelch-like protein 34; Kelch like family member 34; BTB domain containing | Kelch-like protein 30; Kelch like family member 30; BTB domain containing | 0.583 |
KLHL34 | LMOD2 | ENSP00000368813 | ENSP00000411932 | Kelch-like protein 34; Kelch like family member 34; BTB domain containing | Leiomodin-2; Mediates nucleation of actin filaments and thereby promotes actin polymerization. Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function | 0.587 |