PLEKHN1 protein (human) - STRING database

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PLEKHN1

Pleckstrin homology domain containing N1 (611 aa)

Predicted Functional Partners:

SAMD11

0.679

PERM1

0.674

KLHL17

0.624

TFAP2E

0.553

ZCCHC10

0.530

ZNF396

0.530

TMEM212

0.511

PRTG

0.498

C3orf67

0.479

NOC2L

0.469

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3orf67	PLEKHN1	ENSP00000295966	ENSP00000368720	Uncharacterized protein C3orf67; Chromosome 3 open reading frame 67	Pleckstrin homology domain containing N1	0.479
C3orf67	TMEM212	ENSP00000295966	ENSP00000334072	Uncharacterized protein C3orf67; Chromosome 3 open reading frame 67	Transmembrane protein 212	0.511
C3orf67	ZNF396	ENSP00000295966	ENSP00000302310	Uncharacterized protein C3orf67; Chromosome 3 open reading frame 67	Zinc finger protein 396; Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors; Belongs to the krueppel C2H2-type zinc-finger protein family	0.533
KLHL17	PERM1	ENSP00000343930	ENSP00000414022	Kelch-like protein 17; Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity); BTB domain containing	PGC-1 and ERR-induced regulator in muscle protein 1; Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4	0.451
KLHL17	PLEKHN1	ENSP00000343930	ENSP00000368720	Kelch-like protein 17; Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity); BTB domain containing	Pleckstrin homology domain containing N1	0.624
KLHL17	SAMD11	ENSP00000343930	ENSP00000342313	Kelch-like protein 17; Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity); BTB domain containing	Sterile alpha motif domain-containing protein 11; May play a role in photoreceptor development; Sterile alpha motif domain containing	0.586
NOC2L	PLEKHN1	ENSP00000317992	ENSP00000368720	Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter; Armadillo-like helical domain containing	Pleckstrin homology domain containing N1	0.469
NOC2L	SAMD11	ENSP00000317992	ENSP00000342313	Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter; Armadillo-like helical domain containing	Sterile alpha motif domain-containing protein 11; May play a role in photoreceptor development; Sterile alpha motif domain containing	0.570
PERM1	KLHL17	ENSP00000414022	ENSP00000343930	PGC-1 and ERR-induced regulator in muscle protein 1; Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4	Kelch-like protein 17; Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity); BTB domain containing	0.451
PERM1	PLEKHN1	ENSP00000414022	ENSP00000368720	PGC-1 and ERR-induced regulator in muscle protein 1; Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4	Pleckstrin homology domain containing N1	0.674
PERM1	SAMD11	ENSP00000414022	ENSP00000342313	PGC-1 and ERR-induced regulator in muscle protein 1; Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4	Sterile alpha motif domain-containing protein 11; May play a role in photoreceptor development; Sterile alpha motif domain containing	0.474
PLEKHN1	C3orf67	ENSP00000368720	ENSP00000295966	Pleckstrin homology domain containing N1	Uncharacterized protein C3orf67; Chromosome 3 open reading frame 67	0.479
PLEKHN1	KLHL17	ENSP00000368720	ENSP00000343930	Pleckstrin homology domain containing N1	Kelch-like protein 17; Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity); BTB domain containing	0.624
PLEKHN1	NOC2L	ENSP00000368720	ENSP00000317992	Pleckstrin homology domain containing N1	Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter; Armadillo-like helical domain containing	0.469
PLEKHN1	PERM1	ENSP00000368720	ENSP00000414022	Pleckstrin homology domain containing N1	PGC-1 and ERR-induced regulator in muscle protein 1; Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4	0.674
PLEKHN1	PRTG	ENSP00000368720	ENSP00000373937	Pleckstrin homology domain containing N1	Protogenin; May play a role in anteroposterior axis elongation; Fibronectin type III domain containing	0.498
PLEKHN1	SAMD11	ENSP00000368720	ENSP00000342313	Pleckstrin homology domain containing N1	Sterile alpha motif domain-containing protein 11; May play a role in photoreceptor development; Sterile alpha motif domain containing	0.679
PLEKHN1	TFAP2E	ENSP00000368720	ENSP00000362332	Pleckstrin homology domain containing N1	Transcription factor AP-2-epsilon; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5’-GCCNNNGGC-3’ and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity)	0.553
PLEKHN1	TMEM212	ENSP00000368720	ENSP00000334072	Pleckstrin homology domain containing N1	Transmembrane protein 212	0.511
PLEKHN1	ZCCHC10	ENSP00000368720	ENSP00000423276	Pleckstrin homology domain containing N1	Zinc finger CCHC-type containing 10	0.530

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