| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DMP1 | FGF23 | ENSP00000340935 | ENSP00000237837 | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite; SIBLING family | Fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization | 0.982 |
| DMP1 | MEPE | ENSP00000340935 | ENSP00000416984 | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite; SIBLING family | Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization; SIBLING family | 0.970 |
| DMP1 | PHEX | ENSP00000340935 | ENSP00000368682 | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite; SIBLING family | Phosphate-regulating neutral endopeptidase; Probably involved in bone and dentin mineralization and renal phosphate reabsorption; M13 metallopeptidases | 0.822 |
| DMP1 | PTH | ENSP00000340935 | ENSP00000282091 | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite; SIBLING family | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells; Belongs to the parathyroid hormone family | 0.681 |
| FGF23 | DMP1 | ENSP00000237837 | ENSP00000340935 | Fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite; SIBLING family | 0.982 |
| FGF23 | MEPE | ENSP00000237837 | ENSP00000416984 | Fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization | Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization; SIBLING family | 0.978 |
| FGF23 | PHEX | ENSP00000237837 | ENSP00000368682 | Fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization | Phosphate-regulating neutral endopeptidase; Probably involved in bone and dentin mineralization and renal phosphate reabsorption; M13 metallopeptidases | 0.950 |
| FGF23 | PTH | ENSP00000237837 | ENSP00000282091 | Fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells; Belongs to the parathyroid hormone family | 0.970 |
| MEPE | DMP1 | ENSP00000416984 | ENSP00000340935 | Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization; SIBLING family | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite; SIBLING family | 0.970 |
| MEPE | FGF23 | ENSP00000416984 | ENSP00000237837 | Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization; SIBLING family | Fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization | 0.978 |
| MEPE | PHEX | ENSP00000416984 | ENSP00000368682 | Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization; SIBLING family | Phosphate-regulating neutral endopeptidase; Probably involved in bone and dentin mineralization and renal phosphate reabsorption; M13 metallopeptidases | 0.879 |
| MEPE | PTH | ENSP00000416984 | ENSP00000282091 | Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization; SIBLING family | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells; Belongs to the parathyroid hormone family | 0.646 |
| PEX12 | PEX13 | ENSP00000482609 | ENSP00000295030 | Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins; Peroxins | 0.998 |
| PEX12 | PEX2 | ENSP00000482609 | ENSP00000349543 | Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family | 0.998 |
| PEX12 | PEX5 | ENSP00000482609 | ENSP00000391601 | Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | 0.988 |
| PEX12 | PEX6 | ENSP00000482609 | ENSP00000303511 | Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 0.996 |
| PEX12 | PEX7 | ENSP00000482609 | ENSP00000315680 | Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins | Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import; Belongs to the WD repeat peroxin-7 family | 0.994 |
| PEX12 | PHEX | ENSP00000482609 | ENSP00000368682 | Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins | Phosphate-regulating neutral endopeptidase; Probably involved in bone and dentin mineralization and renal phosphate reabsorption; M13 metallopeptidases | 0.746 |
| PEX13 | PEX12 | ENSP00000295030 | ENSP00000482609 | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins; Peroxins | Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins | 0.998 |
| PEX13 | PEX2 | ENSP00000295030 | ENSP00000349543 | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins; Peroxins | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family | 0.996 |
