TTLL10 protein (human) - STRING database

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TTLL10

Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family (673 aa)

Predicted Functional Partners:

TTLL12

0.783

ZNF653

0.682

RWDD2B

0.596

DCAF6

0.581

ATAT1

0.571

CCNO

0.560

MXRA8

0.544

UBN2

0.541

PELP1

0.540

AGBL5

0.536

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGBL5	TTLL10	ENSP00000353249	ENSP00000368592	Cytosolic carboxypeptidase-like protein 5; Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS/MB21D1, regulating the antiviral activity of CGAS/MB21D1	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	0.536
ATAT1	TTLL10	ENSP00000327832	ENSP00000368592	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates ’Lys-40’ in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...]	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	0.571
ATAT1	TTLL12	ENSP00000327832	ENSP00000216129	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates ’Lys-40’ in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...]	Tubulin--tyrosine ligase-like protein 12; Tubulin tyrosine ligase like 12	0.570
CCNO	TTLL10	ENSP00000282572	ENSP00000368592	Cyclin-O; Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking; Belongs to the cyclin family	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	0.560
DCAF6	TTLL10	ENSP00000356814	ENSP00000368592	DDB1- and CUL4-associated factor 6; Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	0.581
DCAF6	ZNF653	ENSP00000356814	ENSP00000293771	DDB1- and CUL4-associated factor 6; Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex	Zinc finger protein 653; Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity; Zinc fingers C2H2-type	0.738
MXRA8	TTLL10	ENSP00000399229	ENSP00000368592	Matrix remodeling-associated protein 8; May play a role in the maturation and maintenance of blood-brain barrier; V-set domain containing	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	0.544
PELP1	TTLL10	ENSP00000301396	ENSP00000368592	Proline-, glutamic acid- and leucine-rich protein 1; Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence- specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/ [...]	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	0.540
RWDD2B	TTLL10	ENSP00000418693	ENSP00000368592	RWD domain containing 2B	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	0.596
RWDD2B	UBN2	ENSP00000418693	ENSP00000418648	RWD domain containing 2B	Ubinuclein-2; Ubinuclein 2; Belongs to the ubinuclein family	0.737
TTLL10	AGBL5	ENSP00000368592	ENSP00000353249	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	Cytosolic carboxypeptidase-like protein 5; Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS/MB21D1, regulating the antiviral activity of CGAS/MB21D1	0.536
TTLL10	ATAT1	ENSP00000368592	ENSP00000327832	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates ’Lys-40’ in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...]	0.571
TTLL10	CCNO	ENSP00000368592	ENSP00000282572	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	Cyclin-O; Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking; Belongs to the cyclin family	0.560
TTLL10	DCAF6	ENSP00000368592	ENSP00000356814	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	DDB1- and CUL4-associated factor 6; Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex	0.581
TTLL10	MXRA8	ENSP00000368592	ENSP00000399229	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	Matrix remodeling-associated protein 8; May play a role in the maturation and maintenance of blood-brain barrier; V-set domain containing	0.544
TTLL10	PELP1	ENSP00000368592	ENSP00000301396	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	Proline-, glutamic acid- and leucine-rich protein 1; Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence- specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/ [...]	0.540
TTLL10	RWDD2B	ENSP00000368592	ENSP00000418693	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	RWD domain containing 2B	0.596
TTLL10	TTLL12	ENSP00000368592	ENSP00000216129	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	Tubulin--tyrosine ligase-like protein 12; Tubulin tyrosine ligase like 12	0.783
TTLL10	UBN2	ENSP00000368592	ENSP00000418648	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	Ubinuclein-2; Ubinuclein 2; Belongs to the ubinuclein family	0.541
TTLL10	ZNF653	ENSP00000368592	ENSP00000293771	Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family	Zinc finger protein 653; Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity; Zinc fingers C2H2-type	0.682

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