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  • 11.0 [archived version]
STRINGSTRING
SCOC SCOC ATF5 ATF5 MCM3AP MCM3AP LZTS1 LZTS1 FEZ2 FEZ2 LPHN3 LPHN3 SARDH SARDH SRBD1 SRBD1 PRRC2B PRRC2B CRIM1 CRIM1 KIF6 KIF6
"FEZ2" - Fasciculation and elongation protein zeta-2 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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FEZ2Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation (380 aa)    
Predicted Functional Partners:
SCOC
Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family (159 aa)
     
 
  0.948
CRIM1
Cysteine-rich motor neuron 1 protein; May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface (1036 aa)
     
   
  0.813
LZTS1
Leucine zipper putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor; Leucine zipper tumor suppressor family (596 aa)
     
   
  0.752
MCM3AP
Germinal-center associated nuclear protein; Isoform GANP- Essential for the generation of high- affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation- dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein p [...] (1980 aa)
           
  0.691
SRBD1
S1 RNA-binding domain-containing protein 1; S1 RNA binding domain 1 (995 aa)
           
  0.663
LPHN3
Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily (1469 aa)
     
   
  0.659
ATF5
Cyclic AMP-dependent transcription factor ATF-5; Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), ATF5-specific response element (ARE) (consensus- 5’-C[CT]TCT[CT]CCTT[AT]-3’) but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcriptional activity is enhanced by CCND3 and s [...] (282 aa)
           
  0.646
PRRC2B
Protein PRRC2B; Proline rich coiled-coil 2B (2229 aa)
           
  0.613
SARDH
Sarcosine dehydrogenase, mitochondrial; Sarcosine dehydrogenase; Belongs to the GcvT family (918 aa)
           
  0.608
KIF6
Kinesin-like protein KIF6; Kinesin family member 6; Kinesins (814 aa)
     
 
  0.572
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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