node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATF5 | FEZ2 | ENSP00000396954 | ENSP00000368547 | Cyclic AMP-dependent transcription factor ATF-5; Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), ATF5-specific response element (ARE) (consensus- 5’-C[CT]TCT[CT]CCTT[AT]-3’) but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcriptional activity is enhanced by CCND3 and s [...] | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | 0.646 |
ATF5 | LZTS1 | ENSP00000396954 | ENSP00000370981 | Cyclic AMP-dependent transcription factor ATF-5; Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), ATF5-specific response element (ARE) (consensus- 5’-C[CT]TCT[CT]CCTT[AT]-3’) but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcriptional activity is enhanced by CCND3 and s [...] | Leucine zipper putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor; Leucine zipper tumor suppressor family | 0.571 |
CRIM1 | FEZ2 | ENSP00000280527 | ENSP00000368547 | Cysteine-rich motor neuron 1 protein; May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | 0.813 |
FEZ2 | ATF5 | ENSP00000368547 | ENSP00000396954 | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | Cyclic AMP-dependent transcription factor ATF-5; Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), ATF5-specific response element (ARE) (consensus- 5’-C[CT]TCT[CT]CCTT[AT]-3’) but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcriptional activity is enhanced by CCND3 and s [...] | 0.646 |
FEZ2 | CRIM1 | ENSP00000368547 | ENSP00000280527 | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | Cysteine-rich motor neuron 1 protein; May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface | 0.813 |
FEZ2 | KIF6 | ENSP00000368547 | ENSP00000287152 | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | Kinesin-like protein KIF6; Kinesin family member 6; Kinesins | 0.572 |
FEZ2 | LPHN3 | ENSP00000368547 | ENSP00000422533 | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | 0.659 |
FEZ2 | LZTS1 | ENSP00000368547 | ENSP00000370981 | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | Leucine zipper putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor; Leucine zipper tumor suppressor family | 0.752 |
FEZ2 | MCM3AP | ENSP00000368547 | ENSP00000380820 | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | Germinal-center associated nuclear protein; Isoform GANP- Essential for the generation of high- affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation- dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein p [...] | 0.691 |
FEZ2 | PRRC2B | ENSP00000368547 | ENSP00000349856 | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | Protein PRRC2B; Proline rich coiled-coil 2B | 0.613 |
FEZ2 | SARDH | ENSP00000368547 | ENSP00000360938 | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | Sarcosine dehydrogenase, mitochondrial; Sarcosine dehydrogenase; Belongs to the GcvT family | 0.608 |
FEZ2 | SCOC | ENSP00000368547 | ENSP00000477352 | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family | 0.948 |
FEZ2 | SRBD1 | ENSP00000368547 | ENSP00000263736 | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | S1 RNA-binding domain-containing protein 1; S1 RNA binding domain 1 | 0.663 |
KIF6 | FEZ2 | ENSP00000287152 | ENSP00000368547 | Kinesin-like protein KIF6; Kinesin family member 6; Kinesins | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | 0.572 |
LPHN3 | FEZ2 | ENSP00000422533 | ENSP00000368547 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | 0.659 |
LPHN3 | SRBD1 | ENSP00000422533 | ENSP00000263736 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | S1 RNA-binding domain-containing protein 1; S1 RNA binding domain 1 | 0.657 |
LZTS1 | ATF5 | ENSP00000370981 | ENSP00000396954 | Leucine zipper putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor; Leucine zipper tumor suppressor family | Cyclic AMP-dependent transcription factor ATF-5; Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus- 5’- GTGACGT[AC][AG]-3’), ATF5-specific response element (ARE) (consensus- 5’-C[CT]TCT[CT]CCTT[AT]-3’) but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcriptional activity is enhanced by CCND3 and s [...] | 0.571 |
LZTS1 | FEZ2 | ENSP00000370981 | ENSP00000368547 | Leucine zipper putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor; Leucine zipper tumor suppressor family | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | 0.752 |
MCM3AP | FEZ2 | ENSP00000380820 | ENSP00000368547 | Germinal-center associated nuclear protein; Isoform GANP- Essential for the generation of high- affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation- dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein p [...] | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | 0.691 |
PRRC2B | FEZ2 | ENSP00000349856 | ENSP00000368547 | Protein PRRC2B; Proline rich coiled-coil 2B | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | 0.613 |