• Version:
  • 11.0 [archived version]
STRINGSTRING
NDC80 NDC80 C16orf52 C16orf52 CENPBD1 CENPBD1 C4orf46 C4orf46 DDX39A DDX39A DCBLD2 DCBLD2 RWDD2A RWDD2A SRPK2 SRPK2
"C4orf46" - Renal cancer differentiation gene 1 protein in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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C4orf46Renal cancer differentiation gene 1 protein; Chromosome 4 open reading frame 46 (113 aa)    
Predicted Functional Partners:
CENPBD1
CENPB DNA-binding domain-containing protein 1; Helix-turn-helix CENPB type domain containing (187 aa)
           
  0.473
DCBLD2
Discoidin, CUB and LCCL domain containing 2 (775 aa)
           
  0.457
SRPK2
SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] (699 aa)
       
      0.442
RWDD2A
RWD domain containing 2A (292 aa)
       
      0.442
NDC80
Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spin [...] (642 aa)
           
  0.424
DDX39A
ATP-dependent RNA helicase DDX39A; Isoform 1- Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily (427 aa)
           
  0.422
C16orf52
Uncharacterized protein C16orf52; Chromosome 16 open reading frame 52 (167 aa)
           
  0.405
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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