• Version:
  • 11.0 [archived version]
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LRRC9 LRRC9 TXLNB TXLNB RPS15 RPS15 SPCS2 SPCS2 SERP2 SERP2 SPCS1 SPCS1 SEC11C SEC11C SEC61B SEC61B DAD1 DAD1 TMED6 TMED6 TMED10 TMED10
"SERP2" - Stress-associated endoplasmic reticulum protein 2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SERP2Stress-associated endoplasmic reticulum protein 2; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential) (65 aa)    
Predicted Functional Partners:
SEC61B
Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum; Belongs to the SEC61-beta family (96 aa)
     
   
  0.822
SEC11C
Signal peptidase complex catalytic subunit SEC11C; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (192 aa)
     
        0.822
LRRC9
Leucine-rich repeat-containing protein 9; Leucine rich repeat containing 9 (1453 aa)
     
   
  0.802
SPCS1
Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum; Belongs to the SPCS1 family (169 aa)
     
   
  0.775
TMED10
Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...] (219 aa)
     
        0.699
TMED6
Transmembrane p24 trafficking protein 6 (240 aa)
     
        0.676
DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation. Loss of the DAD1 protein triggers apoptosis; Belongs to the DAD/OST2 family (113 aa)
     
   
  0.662
SPCS2
Signal peptidase complex subunit 2; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (226 aa)
     
        0.638
TXLNB
Beta-taxilin; Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic; Belongs to the taxilin family (684 aa)
           
  0.620
RPS15
Ribosomal protein S15 (145 aa)
     
   
  0.605
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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