| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARL6IP4 | GPALPP1 | ENSP00000313422 | ENSP00000368447 | ADP-ribosylation factor-like protein 6-interacting protein 4; Involved in modulating alternative pre-mRNA splicing with either 5’ distal site activation or preferential use of 3’ proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA | GPALPP motifs containing 1 | 0.537 |
| ARMCX1 | GPALPP1 | ENSP00000361917 | ENSP00000368447 | Armadillo repeat-containing X-linked protein 1; Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1; Armadillo repeat containing | GPALPP motifs containing 1 | 0.482 |
| CLK2 | GPALPP1 | ENSP00000357345 | ENSP00000368447 | Dual specificity protein kinase CLK2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphory [...] | GPALPP motifs containing 1 | 0.502 |
| CLK2 | PNN | ENSP00000357345 | ENSP00000216832 | Dual specificity protein kinase CLK2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphory [...] | Pinin; Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5’CAGGTG-3’. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulatio [...] | 0.698 |
| CSRNP1 | GPALPP1 | ENSP00000273153 | ENSP00000368447 | Cysteine/serine-rich nuclear protein 1; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis; Belongs to the AXUD1 family | GPALPP motifs containing 1 | 0.402 |
| DDIAS | GPALPP1 | ENSP00000435421 | ENSP00000368447 | DNA damage-induced apoptosis suppressor protein; May be an anti-apoptotic protein involved in DNA repair or cell survival | GPALPP motifs containing 1 | 0.503 |
| GPALPP1 | ARL6IP4 | ENSP00000368447 | ENSP00000313422 | GPALPP motifs containing 1 | ADP-ribosylation factor-like protein 6-interacting protein 4; Involved in modulating alternative pre-mRNA splicing with either 5’ distal site activation or preferential use of 3’ proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA | 0.537 |
| GPALPP1 | ARMCX1 | ENSP00000368447 | ENSP00000361917 | GPALPP motifs containing 1 | Armadillo repeat-containing X-linked protein 1; Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1; Armadillo repeat containing | 0.482 |
| GPALPP1 | CLK2 | ENSP00000368447 | ENSP00000357345 | GPALPP motifs containing 1 | Dual specificity protein kinase CLK2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphory [...] | 0.502 |
| GPALPP1 | CSRNP1 | ENSP00000368447 | ENSP00000273153 | GPALPP motifs containing 1 | Cysteine/serine-rich nuclear protein 1; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis; Belongs to the AXUD1 family | 0.402 |
| GPALPP1 | DDIAS | ENSP00000368447 | ENSP00000435421 | GPALPP motifs containing 1 | DNA damage-induced apoptosis suppressor protein; May be an anti-apoptotic protein involved in DNA repair or cell survival | 0.503 |
| GPALPP1 | GTPBP8 | ENSP00000368447 | ENSP00000373176 | GPALPP motifs containing 1 | GTP binding protein 8; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. EngB GTPase family | 0.657 |
| GPALPP1 | L1TD1 | ENSP00000368447 | ENSP00000419901 | GPALPP motifs containing 1 | LINE1 type transposase domain containing 1; Belongs to the transposase 22 family | 0.412 |
| GPALPP1 | PNN | ENSP00000368447 | ENSP00000216832 | GPALPP motifs containing 1 | Pinin; Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5’CAGGTG-3’. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulatio [...] | 0.511 |
| GPALPP1 | SUGP2 | ENSP00000368447 | ENSP00000472286 | GPALPP motifs containing 1 | SURP and G-patch domain-containing protein 2; May play a role in mRNA splicing; G-patch domain containing | 0.489 |
| GPALPP1 | TAMM41 | ENSP00000368447 | ENSP00000398596 | GPALPP motifs containing 1 | Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane (By similarity); Belongs to the TAM41 family | 0.419 |
| GTPBP8 | GPALPP1 | ENSP00000373176 | ENSP00000368447 | GTP binding protein 8; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. EngB GTPase family | GPALPP motifs containing 1 | 0.657 |
| L1TD1 | GPALPP1 | ENSP00000419901 | ENSP00000368447 | LINE1 type transposase domain containing 1; Belongs to the transposase 22 family | GPALPP motifs containing 1 | 0.412 |
| PNN | CLK2 | ENSP00000216832 | ENSP00000357345 | Pinin; Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5’CAGGTG-3’. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulatio [...] | Dual specificity protein kinase CLK2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphory [...] | 0.698 |
| PNN | GPALPP1 | ENSP00000216832 | ENSP00000368447 | Pinin; Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5’CAGGTG-3’. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulatio [...] | GPALPP motifs containing 1 | 0.511 |
