• Version:
  • 11.0 [archived version]
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C1orf27 C1orf27 NACA2 NACA2 PHB PHB BCAP29 BCAP29 COX4I1 COX4I1 COG5 COG5 VDAC1 VDAC1 DUS4L DUS4L PRKAR2B PRKAR2B GPR22 GPR22 GPX4 GPX4
"BCAP29" - B-cell receptor-associated protein 29 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
BCAP29B-cell receptor-associated protein 29; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity); Belongs to the BCAP29/BCAP31 family (348 aa)    
Predicted Functional Partners:
DUS4L
tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (317 aa)
 
 
   
  0.925
PHB
Prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (272 aa)
     
 
  0.843
COG5
Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function; Belongs to the COG5 family (860 aa)
     
   
  0.840
COX4I1
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport (169 aa)
       
      0.826
NACA2
Nascent polypeptide-associated complex subunit alpha-2; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity) (215 aa)
       
      0.824
PRKAR2B
cAMP-dependent protein kinase type II-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase (418 aa)
           
  0.776
GPR22
Probable G-protein coupled receptor 22; Orphan receptor; G protein-coupled receptors, Class A orphans (433 aa)
           
  0.767
GPX4
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-depende [...] (197 aa)
     
   
  0.741
VDAC1
Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition p [...] (283 aa)
     
      0.740
C1orf27
Protein odr-4 homolog; May play a role in the trafficking of a subset of G- protein coupled receptors; Belongs to the ODR-4 family (454 aa)
     
   
  0.666
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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