| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GFAP | GRM3 | ENSP00000468500 | ENSP00000355316 | Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells | Metabotropic glutamate receptor 3; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity; Glutamate metabotropic receptors | 0.681 |
| GFAP | KCTD4 | ENSP00000468500 | ENSP00000368402 | Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells | BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4 | 0.542 |
| GFAP | OMG | ENSP00000468500 | ENSP00000247271 | Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells | Oligodendrocyte-myelin glycoprotein; Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system | 0.723 |
| GFAP | PLP1 | ENSP00000468500 | ENSP00000481006 | Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells | Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; Belongs to the myelin proteolipid protein family | 0.831 |
| GFAP | TNR | ENSP00000468500 | ENSP00000356646 | Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells | Tenascin-R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repuls [...] | 0.612 |
| GRM3 | GFAP | ENSP00000355316 | ENSP00000468500 | Metabotropic glutamate receptor 3; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity; Glutamate metabotropic receptors | Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells | 0.681 |
| GRM3 | KCTD4 | ENSP00000355316 | ENSP00000368402 | Metabotropic glutamate receptor 3; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity; Glutamate metabotropic receptors | BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4 | 0.528 |
| GRM3 | NMS | ENSP00000355316 | ENSP00000366061 | Metabotropic glutamate receptor 3; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity; Glutamate metabotropic receptors | Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Endogenous ligands | 0.900 |
| GRM3 | PLP1 | ENSP00000355316 | ENSP00000481006 | Metabotropic glutamate receptor 3; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity; Glutamate metabotropic receptors | Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; Belongs to the myelin proteolipid protein family | 0.577 |
| KCTD4 | GFAP | ENSP00000368402 | ENSP00000468500 | BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4 | Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells | 0.542 |
| KCTD4 | GRM3 | ENSP00000368402 | ENSP00000355316 | BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4 | Metabotropic glutamate receptor 3; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity; Glutamate metabotropic receptors | 0.528 |
| KCTD4 | KIAA1191 | ENSP00000368402 | ENSP00000298569 | BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4 | Putative monooxygenase p33MONOX; Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth; Belongs to the P33MONOX family | 0.557 |
| KCTD4 | NMS | ENSP00000368402 | ENSP00000366061 | BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4 | Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Endogenous ligands | 0.644 |
| KCTD4 | OMG | ENSP00000368402 | ENSP00000247271 | BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4 | Oligodendrocyte-myelin glycoprotein; Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system | 0.570 |
| KCTD4 | PLP1 | ENSP00000368402 | ENSP00000481006 | BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4 | Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; Belongs to the myelin proteolipid protein family | 0.528 |
| KCTD4 | PNRC2 | ENSP00000368402 | ENSP00000334840 | BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4 | Proline-rich nuclear receptor coactivator 2; Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5’ UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping e [...] | 0.565 |
| KCTD4 | PSD3 | ENSP00000368402 | ENSP00000324127 | BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4 | PH and SEC7 domain-containing protein 3; Guanine nucleotide exchange factor for ARF6; Pleckstrin homology domain containing | 0.682 |
| KCTD4 | SERPINI1 | ENSP00000368402 | ENSP00000295777 | BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4 | Neuroserpin; Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable); Serpin peptidase inhibitors | 0.570 |
| KCTD4 | TNR | ENSP00000368402 | ENSP00000356646 | BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4 | Tenascin-R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repuls [...] | 0.539 |
| KIAA1191 | KCTD4 | ENSP00000298569 | ENSP00000368402 | Putative monooxygenase p33MONOX; Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth; Belongs to the P33MONOX family | BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4 | 0.557 |
