• Version:
  • 11.0 [archived version]
STRINGSTRING
DDX43 DDX43 KLF12 KLF12 IL1RAPL1 IL1RAPL1 PAGE2B PAGE2B BCOR BCOR NEUROD2 NEUROD2 MAGEB10 MAGEB10 SPATA3 SPATA3 OR5I1 OR5I1 RPL18A RPL18A PPP1R15A PPP1R15A
"MAGEB10" - Melanoma-associated antigen B10 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MAGEB10Melanoma-associated antigen B10; MAGE family member B10 (347 aa)    
Predicted Functional Partners:
KLF12
Krueppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter; Belongs to the Sp1 C2H2-type zinc-finger protein family (402 aa)
           
  0.669
IL1RAPL1
Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family (696 aa)
           
  0.659
PAGE2B
PAGE family member 2B; Belongs to the GAGE family (111 aa)
           
  0.630
SPATA3
Spermatogenesis-associated protein 3; Spermatogenesis associated 3 (192 aa)
           
  0.596
BCOR
BCL-6 corepressor; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 ’Lys-4’ ( [...] (1755 aa)
           
  0.560
RPL18A
Ribosomal protein L18a (176 aa)
       
      0.519
OR5I1
Olfactory receptor 5I1; Odorant receptor; Olfactory receptors, family 5 (314 aa)
           
  0.473
DDX43
Probable ATP-dependent RNA helicase DDX43; DEAD-box helicase 43 (648 aa)
           
  0.452
NEUROD2
Neurogenic differentiation factor 2; Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocort [...] (382 aa)
           
  0.450
PPP1R15A
Protein phosphatase 1 regulatory subunit 15A; Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on ’Ser-15’ (674 aa)
           
  0.445
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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