node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCOR | IL1RAPL1 | ENSP00000367705 | ENSP00000368278 | BCL-6 corepressor; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 ’Lys-4’ ( [...] | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family | 0.482 |
BCOR | KLF12 | ENSP00000367705 | ENSP00000366897 | BCL-6 corepressor; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 ’Lys-4’ ( [...] | Krueppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter; Belongs to the Sp1 C2H2-type zinc-finger protein family | 0.459 |
BCOR | MAGEB10 | ENSP00000367705 | ENSP00000368304 | BCL-6 corepressor; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 ’Lys-4’ ( [...] | Melanoma-associated antigen B10; MAGE family member B10 | 0.560 |
DDX43 | MAGEB10 | ENSP00000359361 | ENSP00000368304 | Probable ATP-dependent RNA helicase DDX43; DEAD-box helicase 43 | Melanoma-associated antigen B10; MAGE family member B10 | 0.452 |
IL1RAPL1 | BCOR | ENSP00000368278 | ENSP00000367705 | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family | BCL-6 corepressor; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 ’Lys-4’ ( [...] | 0.482 |
IL1RAPL1 | KLF12 | ENSP00000368278 | ENSP00000366897 | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family | Krueppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter; Belongs to the Sp1 C2H2-type zinc-finger protein family | 0.423 |
IL1RAPL1 | MAGEB10 | ENSP00000368278 | ENSP00000368304 | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family | Melanoma-associated antigen B10; MAGE family member B10 | 0.659 |
KLF12 | BCOR | ENSP00000366897 | ENSP00000367705 | Krueppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter; Belongs to the Sp1 C2H2-type zinc-finger protein family | BCL-6 corepressor; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 ’Lys-4’ ( [...] | 0.459 |
KLF12 | IL1RAPL1 | ENSP00000366897 | ENSP00000368278 | Krueppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter; Belongs to the Sp1 C2H2-type zinc-finger protein family | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family | 0.423 |
KLF12 | MAGEB10 | ENSP00000366897 | ENSP00000368304 | Krueppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter; Belongs to the Sp1 C2H2-type zinc-finger protein family | Melanoma-associated antigen B10; MAGE family member B10 | 0.669 |
MAGEB10 | BCOR | ENSP00000368304 | ENSP00000367705 | Melanoma-associated antigen B10; MAGE family member B10 | BCL-6 corepressor; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 ’Lys-4’ ( [...] | 0.560 |
MAGEB10 | DDX43 | ENSP00000368304 | ENSP00000359361 | Melanoma-associated antigen B10; MAGE family member B10 | Probable ATP-dependent RNA helicase DDX43; DEAD-box helicase 43 | 0.452 |
MAGEB10 | IL1RAPL1 | ENSP00000368304 | ENSP00000368278 | Melanoma-associated antigen B10; MAGE family member B10 | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family | 0.659 |
MAGEB10 | KLF12 | ENSP00000368304 | ENSP00000366897 | Melanoma-associated antigen B10; MAGE family member B10 | Krueppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter; Belongs to the Sp1 C2H2-type zinc-finger protein family | 0.669 |
MAGEB10 | NEUROD2 | ENSP00000368304 | ENSP00000306754 | Melanoma-associated antigen B10; MAGE family member B10 | Neurogenic differentiation factor 2; Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocort [...] | 0.450 |
MAGEB10 | OR5I1 | ENSP00000368304 | ENSP00000301532 | Melanoma-associated antigen B10; MAGE family member B10 | Olfactory receptor 5I1; Odorant receptor; Olfactory receptors, family 5 | 0.473 |
MAGEB10 | PAGE2B | ENSP00000368304 | ENSP00000364110 | Melanoma-associated antigen B10; MAGE family member B10 | PAGE family member 2B; Belongs to the GAGE family | 0.630 |
MAGEB10 | PPP1R15A | ENSP00000368304 | ENSP00000200453 | Melanoma-associated antigen B10; MAGE family member B10 | Protein phosphatase 1 regulatory subunit 15A; Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on ’Ser-15’ | 0.445 |
MAGEB10 | RPL18A | ENSP00000368304 | ENSP00000222247 | Melanoma-associated antigen B10; MAGE family member B10 | Ribosomal protein L18a | 0.519 |
MAGEB10 | SPATA3 | ENSP00000368304 | ENSP00000388895 | Melanoma-associated antigen B10; MAGE family member B10 | Spermatogenesis-associated protein 3; Spermatogenesis associated 3 | 0.596 |