• Version:
  • 11.0 [archived version]
STRINGSTRING
GAGE2E GAGE2E GAGE12G GAGE12G GAGE12F GAGE12F NR0B1 NR0B1 GAGE2A GAGE2A SSX1 SSX1 GAGE1 GAGE1 MAGEB2 MAGEB2 SSX2 SSX2 CPXCR1 CPXCR1 AIRE AIRE
"MAGEB2" - Melanoma-associated antigen B2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAGEB2Melanoma-associated antigen B2; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex; MAGE family (319 aa)    
Predicted Functional Partners:
NR0B1
Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity); Belongs to the nuclear hormone receptor family. NR0 subfamily (470 aa)
      
   
  0.661
CPXCR1
CPX chromosome region, candidate 1 (301 aa)
            
  0.656
GAGE12F
G antigen 12F; Belongs to the GAGE family (117 aa)
      
   
  0.628
GAGE2E
G antigen 2E (110 aa)
      
   
  0.625
AIRE
Autoimmune regulator; Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5’-ATTGGTTA-3’ combined with a 5’-TTATTA-3’ box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at ’Lys-4’, not phos [...] (545 aa)
        
 
  0.605
GAGE12G
G antigen 12G; Belongs to the GAGE family (117 aa)
      
   
  0.597
GAGE2A
G antigen 2A (116 aa)
      
   
  0.596
SSX2
Synovial sarcoma, X breakpoint 2; SSX family member 2 (223 aa)
      
   
  0.591
SSX1
Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family (188 aa)
      
   
  0.590
GAGE1
G antigen 1; Belongs to the GAGE family (117 aa)
      
   
  0.589
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]
STRING is part of the ELIXIR infrastructure: it is one of ELIXIR's Core Data Resources.  Learn more >