FTHL17 protein (human) - STRING database

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Score

FTHL17

Ferritin heavy chain like 17 (183 aa)

Predicted Functional Partners:

ACO1

0.711

IREB2

0.692

FMR1NB

0.642

CRISP2

0.631

DKKL1

0.556

OR6X1

0.515

TCEAL5

0.512

LUZP4

0.511

FAM127C

0.507

TEX13B

0.505

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACO1	FTHL17	ENSP00000309477	ENSP00000368207	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding	Ferritin heavy chain like 17	0.711
CRISP2	DKKL1	ENSP00000339155	ENSP00000221498	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility	0.606
CRISP2	FMR1NB	ENSP00000339155	ENSP00000359498	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor	0.676
CRISP2	FTHL17	ENSP00000339155	ENSP00000368207	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	Ferritin heavy chain like 17	0.631
DKKL1	CRISP2	ENSP00000221498	ENSP00000339155	Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	0.606
DKKL1	FMR1NB	ENSP00000221498	ENSP00000359498	Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor	0.598
DKKL1	FTHL17	ENSP00000221498	ENSP00000368207	Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility	Ferritin heavy chain like 17	0.556
DKKL1	LUZP4	ENSP00000221498	ENSP00000360988	Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility	Leucine zipper protein 4; Export adapter involved in mRNA nuclear export in cancer cells. Binds and enhances the RNA-binding activity of the nuclear RNA export factor NXF1. Can restore mRNA export function in cells compromised by loss of mRNA export adapters	0.527
FAM127C	FTHL17	ENSP00000375268	ENSP00000368207	Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member C; Belongs to the FAM127 family	Ferritin heavy chain like 17	0.507
FAM127C	TCEAL5	ENSP00000375268	ENSP00000361765	Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member C; Belongs to the FAM127 family	Transcription elongation factor A protein-like 5; May be involved in transcriptional regulation; Transcription elongation factor A like family	0.550
FMR1NB	CRISP2	ENSP00000359498	ENSP00000339155	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	0.676
FMR1NB	DKKL1	ENSP00000359498	ENSP00000221498	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor	Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility	0.598
FMR1NB	FTHL17	ENSP00000359498	ENSP00000368207	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor	Ferritin heavy chain like 17	0.642
FTHL17	ACO1	ENSP00000368207	ENSP00000309477	Ferritin heavy chain like 17	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding	0.711
FTHL17	CRISP2	ENSP00000368207	ENSP00000339155	Ferritin heavy chain like 17	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	0.631
FTHL17	DKKL1	ENSP00000368207	ENSP00000221498	Ferritin heavy chain like 17	Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility	0.556
FTHL17	FAM127C	ENSP00000368207	ENSP00000375268	Ferritin heavy chain like 17	Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member C; Belongs to the FAM127 family	0.507
FTHL17	FMR1NB	ENSP00000368207	ENSP00000359498	Ferritin heavy chain like 17	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor	0.642
FTHL17	IREB2	ENSP00000368207	ENSP00000258886	Ferritin heavy chain like 17	Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5’- UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3’-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA; Belongs to the aconitase/IPM isomerase family	0.692
FTHL17	LUZP4	ENSP00000368207	ENSP00000360988	Ferritin heavy chain like 17	Leucine zipper protein 4; Export adapter involved in mRNA nuclear export in cancer cells. Binds and enhances the RNA-binding activity of the nuclear RNA export factor NXF1. Can restore mRNA export function in cells compromised by loss of mRNA export adapters	0.511

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