node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDKL1 | CDKL4 | ENSP00000379176 | ENSP00000368080 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | 0.828 |
CDKL1 | DRC1 | ENSP00000379176 | ENSP00000288710 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | 0.544 |
CDKL1 | GPATCH11 | ENSP00000379176 | ENSP00000386772 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | G-patch domain containing 11 | 0.450 |
CDKL1 | NPHP1 | ENSP00000379176 | ENSP00000313169 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photorec [...] | 0.455 |
CDKL1 | TMEM138 | ENSP00000379176 | ENSP00000278826 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Transmembrane protein 138; Required for ciliogenesis | 0.584 |
CDKL4 | CDKL1 | ENSP00000368080 | ENSP00000379176 | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | 0.828 |
CDKL4 | DNMT1 | ENSP00000368080 | ENSP00000352516 | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In a [...] | 0.514 |
CDKL4 | DRC1 | ENSP00000368080 | ENSP00000288710 | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | 0.484 |
CDKL4 | FKBP5 | ENSP00000368080 | ENSP00000444810 | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded; FKBP prolyl isomerases | 0.532 |
CDKL4 | GPATCH11 | ENSP00000368080 | ENSP00000386772 | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | G-patch domain containing 11 | 0.522 |
CDKL4 | MORC1 | ENSP00000368080 | ENSP00000232603 | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | MORC family CW-type zinc finger protein 1; Required for spermatogenesis; Zinc fingers CW-type | 0.433 |
CDKL4 | NPHP1 | ENSP00000368080 | ENSP00000313169 | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photorec [...] | 0.447 |
CDKL4 | TMC2 | ENSP00000368080 | ENSP00000351732 | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | Transmembrane channel-like protein 2; Probable ion channel required for the normal function of cochlear hair cells. Component of the hair cell’s mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity); Transmembrane channel likes | 0.498 |
CDKL4 | TMEM116 | ENSP00000368080 | ENSP00000447731 | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | Transmembrane protein 116 | 0.474 |
CDKL4 | TMEM138 | ENSP00000368080 | ENSP00000278826 | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | Transmembrane protein 138; Required for ciliogenesis | 0.624 |
DNMT1 | CDKL4 | ENSP00000352516 | ENSP00000368080 | DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In a [...] | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | 0.514 |
DRC1 | CDKL1 | ENSP00000288710 | ENSP00000379176 | Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | 0.544 |
DRC1 | CDKL4 | ENSP00000288710 | ENSP00000368080 | Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | 0.484 |
DRC1 | GPATCH11 | ENSP00000288710 | ENSP00000386772 | Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | G-patch domain containing 11 | 0.665 |
FKBP5 | CDKL4 | ENSP00000444810 | ENSP00000368080 | Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded; FKBP prolyl isomerases | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | 0.532 |