• Version:
  • 11.0 [archived version]
STRINGSTRING
TMEM116 TMEM116 DNMT1 DNMT1 TMC2 TMC2 FKBP5 FKBP5 CDKL4 CDKL4 MORC1 MORC1 TMEM138 TMEM138 GPATCH11 GPATCH11 CDKL1 CDKL1 NPHP1 NPHP1 DRC1 DRC1
"CDKL4" - Cyclin-dependent kinase-like 4 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CDKL4Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 (315 aa)    
Predicted Functional Partners:
CDKL1
Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 (358 aa)
   
 
 
0.828
TMEM138
Transmembrane protein 138; Required for ciliogenesis (162 aa)
     
   
  0.624
FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded; FKBP prolyl isomerases (457 aa)
       
      0.532
GPATCH11
G-patch domain containing 11 (285 aa)
           
  0.522
DNMT1
DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In a [...] (1632 aa)
       
 
  0.514
TMC2
Transmembrane channel-like protein 2; Probable ion channel required for the normal function of cochlear hair cells. Component of the hair cell’s mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity); Transmembrane channel likes (906 aa)
           
  0.498
DRC1
Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending (740 aa)
     
   
  0.484
TMEM116
Transmembrane protein 116 (337 aa)
           
  0.474
NPHP1
Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photorec [...] (733 aa)
     
   
  0.447
MORC1
MORC family CW-type zinc finger protein 1; Required for spermatogenesis; Zinc fingers CW-type (984 aa)
           
  0.433
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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