ESD protein (human) - STRING database

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ESD

S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde (282 aa)

Predicted Functional Partners:

ADH5

0.999

PGM1

0.839

PDCD6IP

0.827

NDUFAB1

0.813

PGD

0.802

GLO1

0.793

HAGH

0.783

ADH6

0.762

ADH4

0.736

ACP1

0.729

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACP1	ESD	ENSP00000272067	ENSP00000367992	Low molecular weight phosphotyrosine protein phosphatase; Class II Cys-based phosphatases	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde	0.729
ACP1	GLO1	ENSP00000272067	ENSP00000362463	Low molecular weight phosphotyrosine protein phosphatase; Class II Cys-based phosphatases	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis	0.552
ACP1	NDUFAB1	ENSP00000272067	ENSP00000458770	Low molecular weight phosphotyrosine protein phosphatase; Class II Cys-based phosphatases	Acyl carrier protein, mitochondrial; Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain; Belongs to the acyl carrier protein (ACP) family	0.406
ACP1	PGD	ENSP00000272067	ENSP00000270776	Low molecular weight phosphotyrosine protein phosphatase; Class II Cys-based phosphatases	6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH; Belongs to the 6-phosphogluconate dehydrogenase family	0.567
ACP1	PGM1	ENSP00000272067	ENSP00000360124	Low molecular weight phosphotyrosine protein phosphatase; Class II Cys-based phosphatases	Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family	0.529
ADH4	ESD	ENSP00000265512	ENSP00000367992	Alcohol dehydrogenase 4, pi polypeptide	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde	0.736
ADH5	ESD	ENSP00000296412	ENSP00000367992	Alcohol dehydrogenase class-3; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde	0.999
ADH5	HAGH	ENSP00000296412	ENSP00000380514	Alcohol dehydrogenase class-3; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily	Hydroxyacylglutathione hydrolase, mitochondrial; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family	0.511
ADH6	ESD	ENSP00000378359	ENSP00000367992	Alcohol dehydrogenase 6	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde	0.762
ESD	ACP1	ENSP00000367992	ENSP00000272067	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde	Low molecular weight phosphotyrosine protein phosphatase; Class II Cys-based phosphatases	0.729
ESD	ADH4	ENSP00000367992	ENSP00000265512	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde	Alcohol dehydrogenase 4, pi polypeptide	0.736
ESD	ADH5	ENSP00000367992	ENSP00000296412	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde	Alcohol dehydrogenase class-3; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily	0.999
ESD	ADH6	ENSP00000367992	ENSP00000378359	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde	Alcohol dehydrogenase 6	0.762
ESD	GLO1	ENSP00000367992	ENSP00000362463	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis	0.793
ESD	HAGH	ENSP00000367992	ENSP00000380514	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde	Hydroxyacylglutathione hydrolase, mitochondrial; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family	0.783
ESD	NDUFAB1	ENSP00000367992	ENSP00000458770	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde	Acyl carrier protein, mitochondrial; Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain; Belongs to the acyl carrier protein (ACP) family	0.813
ESD	PDCD6IP	ENSP00000367992	ENSP00000411825	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde	Programmed cell death 6-interacting protein; Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires [...]	0.827
ESD	PGD	ENSP00000367992	ENSP00000270776	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde	6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH; Belongs to the 6-phosphogluconate dehydrogenase family	0.802
ESD	PGM1	ENSP00000367992	ENSP00000360124	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde	Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family	0.839
GLO1	ACP1	ENSP00000362463	ENSP00000272067	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis	Low molecular weight phosphotyrosine protein phosphatase; Class II Cys-based phosphatases	0.552

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