node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1orf174 | CCDC27 | ENSP00000355306 | ENSP00000294600 | UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family | Coiled-coil domain containing 27 | 0.735 |
C1orf174 | CEP104 | ENSP00000355306 | ENSP00000367476 | UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | 0.642 |
CCDC27 | C1orf174 | ENSP00000294600 | ENSP00000355306 | Coiled-coil domain containing 27 | UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family | 0.735 |
CCDC27 | CEP104 | ENSP00000294600 | ENSP00000367476 | Coiled-coil domain containing 27 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | 0.665 |
CCP110 | CEP104 | ENSP00000370803 | ENSP00000367476 | Centriolar coiled-coil protein of 110 kDa; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and geno [...] | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | 0.781 |
CCP110 | CEP97 | ENSP00000370803 | ENSP00000342510 | Centriolar coiled-coil protein of 110 kDa; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and geno [...] | Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome | 0.997 |
CCP110 | TTBK2 | ENSP00000370803 | ENSP00000267890 | Centriolar coiled-coil protein of 110 kDa; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and geno [...] | Tau-tubulin kinase 2; Serine/threonine kinase that acts as a key regulator of ciliogenesis- controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro | 0.973 |
CEP104 | C1orf174 | ENSP00000367476 | ENSP00000355306 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family | 0.642 |
CEP104 | CCDC27 | ENSP00000367476 | ENSP00000294600 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | Coiled-coil domain containing 27 | 0.665 |
CEP104 | CCP110 | ENSP00000367476 | ENSP00000370803 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | Centriolar coiled-coil protein of 110 kDa; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and geno [...] | 0.781 |
CEP104 | CEP97 | ENSP00000367476 | ENSP00000342510 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome | 0.795 |
CEP104 | RIMBP2 | ENSP00000367476 | ENSP00000261655 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | RIMS-binding protein 2; Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B; Protein phosphatase 1 regulatory subunits | 0.663 |
CEP104 | SLC16A6 | ENSP00000367476 | ENSP00000319991 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | Monocarboxylate transporter 7; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity); Solute carriers | 0.610 |
CEP104 | SLC3A2 | ENSP00000367476 | ENSP00000367123 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | 4F2 cell-surface antigen heavy chain; Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbi [...] | 0.623 |
CEP104 | SLC7A6 | ENSP00000367476 | ENSP00000455064 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | Y+L amino acid transporter 2; Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in mono [...] | 0.640 |
CEP104 | SLC7A7 | ENSP00000367476 | ENSP00000380666 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | Y+L amino acid transporter 1; Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L- arginine in monocytes; Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family | 0.810 |
CEP104 | TTBK2 | ENSP00000367476 | ENSP00000267890 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | Tau-tubulin kinase 2; Serine/threonine kinase that acts as a key regulator of ciliogenesis- controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro | 0.703 |
CEP97 | CCP110 | ENSP00000342510 | ENSP00000370803 | Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome | Centriolar coiled-coil protein of 110 kDa; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and geno [...] | 0.997 |
CEP97 | CEP104 | ENSP00000342510 | ENSP00000367476 | Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip | 0.795 |
CEP97 | TTBK2 | ENSP00000342510 | ENSP00000267890 | Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome | Tau-tubulin kinase 2; Serine/threonine kinase that acts as a key regulator of ciliogenesis- controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro | 0.971 |