• Version:
  • 11.0 [archived version]
STRINGSTRING
SPINK4 SPINK4 SHISA9 SHISA9 IGFALS IGFALS TTC29 TTC29 NAT8L NAT8L ERICH4 ERICH4 MYO18B MYO18B PGA3 PGA3 TMEM184A TMEM184A PDILT PDILT TRIM50 TRIM50
"ERICH4" - Glutamate-rich protein 4 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ERICH4Glutamate-rich protein 4; Glutamate rich 4 (130 aa)    
Predicted Functional Partners:
TTC29
Tetratricopeptide repeat domain containing (501 aa)
           
  0.680
SHISA9
Protein shisa-9; Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity); Belongs to the shisa family. SHISA9 subfamily (424 aa)
           
  0.621
NAT8L
N-acetylaspartate synthetase; Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake; Belongs to the camello family (302 aa)
           
  0.564
TMEM184A
Transmembrane protein 184A; Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity) (413 aa)
           
  0.552
MYO18B
Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (2567 aa)
           
  0.551
IGFALS
Insulin-like growth factor-binding protein complex acid labile subunit; Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion (643 aa)
           
  0.509
SPINK4
Serine peptidase inhibitor, Kazal type 4 (86 aa)
     
   
  0.500
PDILT
Protein disulfide-isomerase-like protein of the testis; Probable redox-inactive chaperone involved in spermatogenesis; Belongs to the protein disulfide isomerase family (584 aa)
           
  0.497
TRIM50
E3 ubiquitin-protein ligase TRIM50; E3 ubiquitin-protein ligase; Ring finger proteins (487 aa)
           
  0.479
PGA3
Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa)
           
  0.475
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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