FAM171A1 protein (human) - STRING database

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FAM171A1

Protein FAM171A1; Family with sequence similarity 171 member A1 (890 aa)

Predicted Functional Partners:

SHANK1

0.706

RADIL

0.619

RASIP1

0.586

C22orf42

0.571

C12orf29

0.567

SMG8

0.556

TOR4A

0.555

C1orf186

0.543

DDX20

0.534

ENSG00000265303

0.508

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C12orf29	C1orf186	ENSP00000349358	ENSP00000356093	Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29	Uncharacterized protein C1orf186; Chromosome 1 open reading frame 186	0.576
C12orf29	FAM171A1	ENSP00000349358	ENSP00000367356	Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29	Protein FAM171A1; Family with sequence similarity 171 member A1	0.567
C12orf29	TOR4A	ENSP00000349358	ENSP00000350102	Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29	Torsin-4A; Torsin family 4 member A	0.596
C1orf186	C12orf29	ENSP00000356093	ENSP00000349358	Uncharacterized protein C1orf186; Chromosome 1 open reading frame 186	Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29	0.576
C1orf186	FAM171A1	ENSP00000356093	ENSP00000367356	Uncharacterized protein C1orf186; Chromosome 1 open reading frame 186	Protein FAM171A1; Family with sequence similarity 171 member A1	0.543
C1orf186	TOR4A	ENSP00000356093	ENSP00000350102	Uncharacterized protein C1orf186; Chromosome 1 open reading frame 186	Torsin-4A; Torsin family 4 member A	0.569
C22orf42	FAM171A1	ENSP00000371529	ENSP00000367356	Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42	Protein FAM171A1; Family with sequence similarity 171 member A1	0.571
DDX20	ENSG00000265303	ENSP00000358716	ENSP00000464167	Probable ATP-dependent RNA helicase DDX20; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm compl [...]	Uncharacterized protein	0.540
DDX20	FAM171A1	ENSP00000358716	ENSP00000367356	Probable ATP-dependent RNA helicase DDX20; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm compl [...]	Protein FAM171A1; Family with sequence similarity 171 member A1	0.534
DDX20	SMG8	ENSP00000358716	ENSP00000438748	Probable ATP-dependent RNA helicase DDX20; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm compl [...]	Protein SMG8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome-SURF complex and to suppress SMG1 kinase activity until the ribosome-SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity	0.597
ENSG00000265303	DDX20	ENSP00000464167	ENSP00000358716	Uncharacterized protein	Probable ATP-dependent RNA helicase DDX20; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm compl [...]	0.540
ENSG00000265303	FAM171A1	ENSP00000464167	ENSP00000367356	Uncharacterized protein	Protein FAM171A1; Family with sequence similarity 171 member A1	0.508
FAM171A1	C12orf29	ENSP00000367356	ENSP00000349358	Protein FAM171A1; Family with sequence similarity 171 member A1	Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29	0.567
FAM171A1	C1orf186	ENSP00000367356	ENSP00000356093	Protein FAM171A1; Family with sequence similarity 171 member A1	Uncharacterized protein C1orf186; Chromosome 1 open reading frame 186	0.543
FAM171A1	C22orf42	ENSP00000367356	ENSP00000371529	Protein FAM171A1; Family with sequence similarity 171 member A1	Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42	0.571
FAM171A1	DDX20	ENSP00000367356	ENSP00000358716	Protein FAM171A1; Family with sequence similarity 171 member A1	Probable ATP-dependent RNA helicase DDX20; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm compl [...]	0.534
FAM171A1	ENSG00000265303	ENSP00000367356	ENSP00000464167	Protein FAM171A1; Family with sequence similarity 171 member A1	Uncharacterized protein	0.508
FAM171A1	RADIL	ENSP00000367356	ENSP00000382492	Protein FAM171A1; Family with sequence similarity 171 member A1	Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family	0.619
FAM171A1	RASIP1	ENSP00000367356	ENSP00000222145	Protein FAM171A1; Family with sequence similarity 171 member A1	Ras-interacting protein 1; Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRA [...]	0.586
FAM171A1	SHANK1	ENSP00000367356	ENSP00000293441	Protein FAM171A1; Family with sequence similarity 171 member A1	SH3 and multiple ankyrin repeat domains protein 1; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction; Ankyrin repeat domain containing	0.706

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