GRXCR2 protein (human) - STRING database

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GRXCR2

Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes (248 aa)

Predicted Functional Partners:

PLAC8L1

0.828

YIPF5

0.761

RBM27

0.714

BLOC1S2

0.652

LOXHD1

0.604

GIPC3

0.600

CAP1

0.559

CAP2

0.559

STRC

0.556

PRELID2

0.552

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLOC1S2	GRXCR2	ENSP00000359398	ENSP00000367214	Biogenesis of lysosome-related organelles complex 1 subunit 2; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in l [...]	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes	0.652
CAP1	CAP2	ENSP00000361883	ENSP00000229922	Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family	Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family	0.926
CAP1	GRXCR2	ENSP00000361883	ENSP00000367214	Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes	0.559
CAP2	CAP1	ENSP00000229922	ENSP00000361883	Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family	Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family	0.926
CAP2	GRXCR2	ENSP00000229922	ENSP00000367214	Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes	0.559
GIPC3	GRXCR2	ENSP00000319254	ENSP00000367214	PDZ domain-containing protein GIPC3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion; Deafness associated genes	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes	0.600
GIPC3	LOXHD1	ENSP00000319254	ENSP00000300591	PDZ domain-containing protein GIPC3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion; Deafness associated genes	Lipoxygenase homology domain-containing protein 1; Involved in hearing. Required for normal function of hair cells in the inner ear (By similarity); Deafness associated genes	0.614
GIPC3	STRC	ENSP00000319254	ENSP00000401513	PDZ domain-containing protein GIPC3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion; Deafness associated genes	Stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia; Belongs to the stereocilin family	0.476
GRXCR2	BLOC1S2	ENSP00000367214	ENSP00000359398	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes	Biogenesis of lysosome-related organelles complex 1 subunit 2; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in l [...]	0.652
GRXCR2	CAP1	ENSP00000367214	ENSP00000361883	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes	Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family	0.559
GRXCR2	CAP2	ENSP00000367214	ENSP00000229922	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes	Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family	0.559
GRXCR2	GIPC3	ENSP00000367214	ENSP00000319254	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes	PDZ domain-containing protein GIPC3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion; Deafness associated genes	0.600
GRXCR2	LOXHD1	ENSP00000367214	ENSP00000300591	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes	Lipoxygenase homology domain-containing protein 1; Involved in hearing. Required for normal function of hair cells in the inner ear (By similarity); Deafness associated genes	0.604
GRXCR2	PLAC8L1	ENSP00000367214	ENSP00000309087	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes	PLAC8-like protein 1; PLAC8 like 1; Belongs to the cornifelin family	0.828
GRXCR2	PRELID2	ENSP00000367214	ENSP00000335675	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes	PRELI domain containing 2	0.552
GRXCR2	RBM27	ENSP00000367214	ENSP00000265271	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes	RNA-binding protein 27; RNA binding motif containing	0.714
GRXCR2	STRC	ENSP00000367214	ENSP00000401513	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes	Stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia; Belongs to the stereocilin family	0.556
GRXCR2	YIPF5	ENSP00000367214	ENSP00000274496	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes	Protein YIPF5; Plays a role in transport between endoplasmic reticulum and Golgi; Yip1 domain containing	0.761
LOXHD1	GIPC3	ENSP00000300591	ENSP00000319254	Lipoxygenase homology domain-containing protein 1; Involved in hearing. Required for normal function of hair cells in the inner ear (By similarity); Deafness associated genes	PDZ domain-containing protein GIPC3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion; Deafness associated genes	0.614
LOXHD1	GRXCR2	ENSP00000300591	ENSP00000367214	Lipoxygenase homology domain-containing protein 1; Involved in hearing. Required for normal function of hair cells in the inner ear (By similarity); Deafness associated genes	Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes	0.604

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