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  • 11.0 [archived version]
STRINGSTRING
TPX2 TPX2 FHL1 FHL1 GLIPR1 GLIPR1 ASPRV1 ASPRV1 CRIP2 CRIP2 TMEM37 TMEM37 GLIPR2 GLIPR2 GLIPR1L1 GLIPR1L1 BECN1 BECN1 MYO15A MYO15A SH3RF1 SH3RF1
"GLIPR2" - Golgi-associated plant pathogenesis-related protein 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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GLIPR2Golgi-associated plant pathogenesis-related protein 1; GLI pathogenesis related 2; CAP superfamily (154 aa)    
Predicted Functional Partners:
GLIPR1
Glioma pathogenesis-related protein 1; GLI pathogenesis related family 1 (266 aa)
   
   
  0.795
CRIP2
Cysteine rich protein 2; LIM domain containing (282 aa)
           
  0.672
TMEM37
Voltage-dependent calcium channel gamma-like subunit; Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity) (190 aa)
           
  0.660
GLIPR1L1
GLIPR1-like protein 1; Plays a role in the binding between sperm and oocytes. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region; GLI pathogenesis related family 1 (233 aa)
   
     
  0.654
BECN1
Beclin-1; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways- PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Invo [...] (450 aa)
     
 
  0.634
MYO15A
Unconventional myosin-XV; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (3530 aa)
     
 
  0.616
FHL1
Four and a half LIM domains protein 1; May have an involvement in muscle development or hypertrophy; LIM domain containing (323 aa)
           
  0.588
SH3RF1
E3 ubiquitin-protein ligase SH3RF1; Acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9) (By similarity). May be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane; Belongs to the SH3RF family (888 aa)
     
   
  0.583
TPX2
Targeting protein for Xklp2; Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at ’Thr-288’ and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin- alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate [...] (747 aa)
           
  0.559
ASPRV1
Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes (343 aa)
           
  0.527
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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