| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CAPN9 | GKN1 | ENSP00000271971 | ENSP00000367172 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing | 0.901 |
| GKN1 | CAPN9 | ENSP00000367172 | ENSP00000271971 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family | 0.901 |
| GKN1 | LIPF | ENSP00000367172 | ENSP00000377900 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing | Lipase F, gastric type; Lipases | 0.557 |
| GKN1 | MAPK14 | ENSP00000367172 | ENSP00000229795 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.527 |
| GKN1 | METTL13 | ENSP00000367172 | ENSP00000354920 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing | Methyltransferase-like protein 13; Methyltransferase like 13; Belongs to the methyltransferase superfamily | 0.532 |
| GKN1 | NAA10 | ENSP00000367172 | ENSP00000417763 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing | N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabili [...] | 0.678 |
| GKN1 | NKX6-3 | ENSP00000367172 | ENSP00000429553 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing | Homeobox protein Nkx-6.3; Putative transcription factor, which may be involved in patterning of central nervous system and pancreas; NKL subclass homeoboxes and pseudogenes | 0.561 |
| GKN1 | SPAG11B | ENSP00000367172 | ENSP00000381480 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing | Sperm-associated antigen 11A; Sperm associated antigen 11B; Belongs to the SPAG11 family | 0.558 |
| GKN1 | TAS1R3 | ENSP00000367172 | ENSP00000344411 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing | Taste receptor type 1 member 3; Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses | 0.637 |
| GKN1 | TFF1 | ENSP00000367172 | ENSP00000291527 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing | Trefoil factor 1; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine | 0.526 |
| GKN1 | TFF2 | ENSP00000367172 | ENSP00000291526 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity) | 0.568 |
| LIPF | GKN1 | ENSP00000377900 | ENSP00000367172 | Lipase F, gastric type; Lipases | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing | 0.557 |
| MAPK14 | GKN1 | ENSP00000229795 | ENSP00000367172 | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing | 0.527 |
| MAPK14 | NAA10 | ENSP00000229795 | ENSP00000417763 | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabili [...] | 0.590 |
| METTL13 | GKN1 | ENSP00000354920 | ENSP00000367172 | Methyltransferase-like protein 13; Methyltransferase like 13; Belongs to the methyltransferase superfamily | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing | 0.532 |
| METTL13 | NAA10 | ENSP00000354920 | ENSP00000417763 | Methyltransferase-like protein 13; Methyltransferase like 13; Belongs to the methyltransferase superfamily | N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabili [...] | 0.583 |
| NAA10 | GKN1 | ENSP00000417763 | ENSP00000367172 | N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabili [...] | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing | 0.678 |
| NAA10 | MAPK14 | ENSP00000417763 | ENSP00000229795 | N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabili [...] | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.590 |
| NAA10 | METTL13 | ENSP00000417763 | ENSP00000354920 | N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration. Acetylates, and stabili [...] | Methyltransferase-like protein 13; Methyltransferase like 13; Belongs to the methyltransferase superfamily | 0.583 |
| NKX6-3 | GKN1 | ENSP00000429553 | ENSP00000367172 | Homeobox protein Nkx-6.3; Putative transcription factor, which may be involved in patterning of central nervous system and pancreas; NKL subclass homeoboxes and pseudogenes | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing | 0.561 |
