| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GSDMB | LRRC3C | ENSP00000415049 | ENSP00000367157 | Gasdermin-B; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | 0.573 |
| GSDMB | ORMDL3 | ENSP00000415049 | ENSP00000377724 | Gasdermin-B; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling; Belongs to the ORM family | 0.916 |
| GSDMB | ZPBP2 | ENSP00000415049 | ENSP00000335384 | Gasdermin-B; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | Zona pellucida-binding protein 2; Is implicated in sperm-oocyte interaction during fertilization; Immunoglobulin like domain containing | 0.836 |
| IGDCC3 | LRRC3C | ENSP00000332773 | ENSP00000367157 | Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | 0.576 |
| LAPTM4B | LRRC3C | ENSP00000402301 | ENSP00000367157 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTOR [...] | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | 0.554 |
| LAPTM4B | NXPH2 | ENSP00000402301 | ENSP00000272641 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTOR [...] | Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors; Belongs to the neurexophilin family | 0.568 |
| LAPTM4B | TMEM86A | ENSP00000402301 | ENSP00000280734 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTOR [...] | Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A | 0.656 |
| LPHN1 | LRRC3C | ENSP00000340688 | ENSP00000367157 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | 0.703 |
| LPHN1 | NXPH2 | ENSP00000340688 | ENSP00000272641 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors; Belongs to the neurexophilin family | 0.556 |
| LPHN2 | LRRC3C | ENSP00000322270 | ENSP00000367157 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | 0.732 |
| LPHN3 | LRRC3C | ENSP00000422533 | ENSP00000367157 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | 0.703 |
| LRRC3C | GSDMB | ENSP00000367157 | ENSP00000415049 | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | Gasdermin-B; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Probable); Gasdermins | 0.573 |
| LRRC3C | IGDCC3 | ENSP00000367157 | ENSP00000332773 | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing | 0.576 |
| LRRC3C | LAPTM4B | ENSP00000367157 | ENSP00000402301 | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTOR [...] | 0.554 |
| LRRC3C | LPHN1 | ENSP00000367157 | ENSP00000340688 | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | 0.703 |
| LRRC3C | LPHN2 | ENSP00000367157 | ENSP00000322270 | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.732 |
| LRRC3C | LPHN3 | ENSP00000367157 | ENSP00000422533 | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | 0.703 |
| LRRC3C | NXPH2 | ENSP00000367157 | ENSP00000272641 | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors; Belongs to the neurexophilin family | 0.600 |
| LRRC3C | ORMDL3 | ENSP00000367157 | ENSP00000377724 | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling; Belongs to the ORM family | 0.593 |
| LRRC3C | TMEM86A | ENSP00000367157 | ENSP00000280734 | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C | Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A | 0.775 |
