Export your current network:
... as a bitmap image:
file format is 'PNG': portable network graphic
... as a high-resolution bitmap:
same PNG format, but resolution at 400 dpi
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as simple tabular text output:
TSV: tab separated values - can be opened in Excel
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BHLHE41 | HES2 | ENSP00000242728 | ENSP00000367065 | Class E basic helix-loop-helix protein 41; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator- CLOCK-ARNTL/BMAL1 heterodime [...] | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription; Basic helix-loop-helix proteins | 0.443 |
CD99L2 | HES2 | ENSP00000480322 | ENSP00000367065 | CD99 antigen-like protein 2; Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity); Belongs to the CD99 family | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription; Basic helix-loop-helix proteins | 0.407 |
GIPC3 | HES2 | ENSP00000319254 | ENSP00000367065 | PDZ domain-containing protein GIPC3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion; Deafness associated genes | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription; Basic helix-loop-helix proteins | 0.404 |
HES2 | BHLHE41 | ENSP00000367065 | ENSP00000242728 | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription; Basic helix-loop-helix proteins | Class E basic helix-loop-helix protein 41; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator- CLOCK-ARNTL/BMAL1 heterodime [...] | 0.443 |
HES2 | CD99L2 | ENSP00000367065 | ENSP00000480322 | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription; Basic helix-loop-helix proteins | CD99 antigen-like protein 2; Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity); Belongs to the CD99 family | 0.407 |
HES2 | GIPC3 | ENSP00000367065 | ENSP00000319254 | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription; Basic helix-loop-helix proteins | PDZ domain-containing protein GIPC3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion; Deafness associated genes | 0.404 |
HES2 | NEUROG3 | ENSP00000367065 | ENSP00000242462 | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription; Basic helix-loop-helix proteins | Neurogenin-3; Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity); Basic helix-loop-helix proteins | 0.501 |
HES2 | RGS20 | ENSP00000367065 | ENSP00000297313 | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription; Basic helix-loop-helix proteins | Regulator of G-protein signaling 20; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity) | 0.470 |
NEUROG3 | HES2 | ENSP00000242462 | ENSP00000367065 | Neurogenin-3; Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity); Basic helix-loop-helix proteins | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription; Basic helix-loop-helix proteins | 0.501 |
RGS20 | HES2 | ENSP00000297313 | ENSP00000367065 | Regulator of G-protein signaling 20; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity) | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription; Basic helix-loop-helix proteins | 0.470 |