node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADD3 | PLCXD3 | ENSP00000348381 | ENSP00000367032 | Gamma-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin; Belongs to the aldolase class II family. Adducin subfamily | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | 0.511 |
DIP2C | PLCXD3 | ENSP00000280886 | ENSP00000367032 | Disco interacting protein 2 homolog C | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | 0.503 |
MTMR7 | PLCXD3 | ENSP00000180173 | ENSP00000367032 | Myotubularin-related protein 7; Phosphatase that acts on lipids with a phosphoinositol headgroup; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | 0.532 |
PLCXD3 | ADD3 | ENSP00000367032 | ENSP00000348381 | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | Gamma-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin; Belongs to the aldolase class II family. Adducin subfamily | 0.511 |
PLCXD3 | DIP2C | ENSP00000367032 | ENSP00000280886 | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | Disco interacting protein 2 homolog C | 0.503 |
PLCXD3 | MTMR7 | ENSP00000367032 | ENSP00000180173 | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | Myotubularin-related protein 7; Phosphatase that acts on lipids with a phosphoinositol headgroup; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | 0.532 |
PLCXD3 | PLEKHA5 | ENSP00000367032 | ENSP00000404296 | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | Pleckstrin homology domain containing A5 | 0.571 |
PLCXD3 | POGZ | ENSP00000367032 | ENSP00000271715 | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | Pogo transposable element with ZNF domain; Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms; DNA transposon derived genes | 0.521 |
PLCXD3 | SERINC5 | ENSP00000367032 | ENSP00000426237 | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | Serine incorporator 5; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1- acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity) | 0.618 |
PLCXD3 | TMTC2 | ENSP00000367032 | ENSP00000322300 | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | Transmembrane and tetratricopeptide repeat containing 2 | 0.509 |
PLCXD3 | VSNL1 | ENSP00000367032 | ENSP00000384719 | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner; Belongs to the recoverin family | 0.635 |
PLCXD3 | WDR64 | ENSP00000367032 | ENSP00000355510 | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | WD repeat-containing protein 64; WD repeat domain containing | 0.547 |
PLCXD3 | ZNF385B | ENSP00000367032 | ENSP00000386845 | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | Zinc finger protein 385B; May play a role in p53/TP53-mediated apoptosis | 0.671 |
PLEKHA5 | PLCXD3 | ENSP00000404296 | ENSP00000367032 | Pleckstrin homology domain containing A5 | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | 0.571 |
POGZ | PLCXD3 | ENSP00000271715 | ENSP00000367032 | Pogo transposable element with ZNF domain; Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms; DNA transposon derived genes | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | 0.521 |
SERINC5 | PLCXD3 | ENSP00000426237 | ENSP00000367032 | Serine incorporator 5; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1- acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity) | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | 0.618 |
TMTC2 | PLCXD3 | ENSP00000322300 | ENSP00000367032 | Transmembrane and tetratricopeptide repeat containing 2 | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | 0.509 |
TMTC2 | WDR64 | ENSP00000322300 | ENSP00000355510 | Transmembrane and tetratricopeptide repeat containing 2 | WD repeat-containing protein 64; WD repeat domain containing | 0.536 |
VSNL1 | PLCXD3 | ENSP00000384719 | ENSP00000367032 | Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner; Belongs to the recoverin family | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 | 0.635 |
VSNL1 | ZNF385B | ENSP00000384719 | ENSP00000386845 | Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner; Belongs to the recoverin family | Zinc finger protein 385B; May play a role in p53/TP53-mediated apoptosis | 0.470 |