FAM216A protein (human) - STRING database

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FAM216A

Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family (273 aa)

Predicted Functional Partners:

CCDC34

0.713

NOP16

0.662

NIFK

0.643

PSMA4

0.573

KCNC4

0.534

RMDN3

0.512

DKC1

0.438

MAGEA10

0.422

C19orf60

0.407

RFC4

0.400

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C19orf60	FAM216A	ENSP00000351422	ENSP00000366901	Uncharacterized protein C19orf60; Chromosome 19 open reading frame 60	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family	0.407
CCDC34	FAM216A	ENSP00000330240	ENSP00000366901	Coiled-coil domain containing 34	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family	0.713
DKC1	FAM216A	ENSP00000358563	ENSP00000366901	H/ACA ribonucleoprotein complex subunit 4; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the t [...]	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family	0.438
DKC1	NIFK	ENSP00000358563	ENSP00000285814	H/ACA ribonucleoprotein complex subunit 4; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the t [...]	Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing	0.994
DKC1	NOP16	ENSP00000358563	ENSP00000480832	H/ACA ribonucleoprotein complex subunit 4; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the t [...]	NOP16 nucleolar protein; Belongs to the NOP16 family	0.902
FAM216A	C19orf60	ENSP00000366901	ENSP00000351422	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family	Uncharacterized protein C19orf60; Chromosome 19 open reading frame 60	0.407
FAM216A	CCDC34	ENSP00000366901	ENSP00000330240	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family	Coiled-coil domain containing 34	0.713
FAM216A	DKC1	ENSP00000366901	ENSP00000358563	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family	H/ACA ribonucleoprotein complex subunit 4; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the t [...]	0.438
FAM216A	KCNC4	ENSP00000366901	ENSP00000358802	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family	Potassium voltage-gated channel subfamily C member 4; This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient; Potassium voltage-gated channels	0.534
FAM216A	MAGEA10	ENSP00000366901	ENSP00000244096	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family	Melanoma-associated antigen 10; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family	0.422
FAM216A	NIFK	ENSP00000366901	ENSP00000285814	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family	Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing	0.643
FAM216A	NOP16	ENSP00000366901	ENSP00000480832	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family	NOP16 nucleolar protein; Belongs to the NOP16 family	0.662
FAM216A	PSMA4	ENSP00000366901	ENSP00000044462	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family	Proteasome subunit alpha type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...]	0.573
FAM216A	RFC4	ENSP00000366901	ENSP00000376272	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family	Replication factor C subunit 4; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template	0.400
FAM216A	RMDN3	ENSP00000366901	ENSP00000260385	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family	Regulator of microtubule dynamics protein 3; Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis; Belongs to the RMDN family	0.512
KCNC4	FAM216A	ENSP00000358802	ENSP00000366901	Potassium voltage-gated channel subfamily C member 4; This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient; Potassium voltage-gated channels	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family	0.534
MAGEA10	FAM216A	ENSP00000244096	ENSP00000366901	Melanoma-associated antigen 10; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family	0.422
NIFK	DKC1	ENSP00000285814	ENSP00000358563	Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing	H/ACA ribonucleoprotein complex subunit 4; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the t [...]	0.994
NIFK	FAM216A	ENSP00000285814	ENSP00000366901	Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing	Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family	0.643
NIFK	NOP16	ENSP00000285814	ENSP00000480832	Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing	NOP16 nucleolar protein; Belongs to the NOP16 family	0.920

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