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  • 11.0 [archived version]
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ZNF827 ZNF827 FSBP FSBP TFAP2A TFAP2A SRBD1 SRBD1 IDO2 IDO2 KLF12 KLF12 TANC2 TANC2 CTBP1 CTBP1 MAGEB10 MAGEB10 FRMD4A FRMD4A PARD3B PARD3B
"KLF12" - Krueppel-like factor 12 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
KLF12Krueppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter; Belongs to the Sp1 C2H2-type zinc-finger protein family (402 aa)    
Predicted Functional Partners:
TFAP2A
Transcription factor AP-2-alpha; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5’-GCCNNNGGC-3’ and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 [...] (437 aa)
           
  0.711
MAGEB10
Melanoma-associated antigen B10; MAGE family member B10 (347 aa)
           
  0.669
IDO2
Indoleamine 2,3-dioxygenase 2; Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (420 aa)
       
      0.622
TANC2
Protein TANC2; Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2; Belongs to the TANC family (1990 aa)
     
 
  0.591
FSBP
Fibrinogen silencer-binding protein; Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1 (299 aa)
           
  0.583
FRMD4A
FERM domain-containing protein 4A; Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling; FERM domain containing (1039 aa)
           
  0.569
ZNF827
Zinc finger protein 827; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (1077 aa)
           
  0.565
PARD3B
Partitioning defective 3 homolog B; Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions; Belongs to the PAR3 family (1143 aa)
       
 
  0.552
SRBD1
S1 RNA-binding domain-containing protein 1; S1 RNA binding domain 1 (995 aa)
     
 
  0.543
CTBP1
C-terminal-binding protein 1; Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family (440 aa)
       
 
  0.538
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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