HMGN4 protein (human) - STRING database

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HMGN4

High mobility group nucleosomal binding domain 4; Belongs to the HMGN family (90 aa)

Predicted Functional Partners:

TWIST1

0.730

C9orf64

0.685

HMGN1

0.562

WDR26

0.556

POM121L2

0.536

NHS

0.522

SAR1B

0.486

WAS

0.477

SMCHD1

0.475

SCMH1

0.468

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C9orf64	HMGN4	ENSP00000365522	ENSP00000366798	Queuosine salvage protein; Involved in salvaging queuosine	High mobility group nucleosomal binding domain 4; Belongs to the HMGN family	0.685
C9orf64	SAR1B	ENSP00000365522	ENSP00000385432	Queuosine salvage protein; Involved in salvaging queuosine	GTP-binding protein SAR1b; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex; ARF GTPase family	0.519
C9orf64	WDR26	ENSP00000365522	ENSP00000408108	Queuosine salvage protein; Involved in salvaging queuosine	WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta-gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. [...]	0.685
HMGN1	HMGN4	ENSP00000370125	ENSP00000366798	Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity); Belongs to the HMGN family	High mobility group nucleosomal binding domain 4; Belongs to the HMGN family	0.562
HMGN4	C9orf64	ENSP00000366798	ENSP00000365522	High mobility group nucleosomal binding domain 4; Belongs to the HMGN family	Queuosine salvage protein; Involved in salvaging queuosine	0.685
HMGN4	HMGN1	ENSP00000366798	ENSP00000370125	High mobility group nucleosomal binding domain 4; Belongs to the HMGN family	Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity); Belongs to the HMGN family	0.562
HMGN4	NHS	ENSP00000366798	ENSP00000369400	High mobility group nucleosomal binding domain 4; Belongs to the HMGN family	Nance-Horan syndrome protein; May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development; Belongs to the NHS family	0.522
HMGN4	POM121L2	ENSP00000366798	ENSP00000392726	High mobility group nucleosomal binding domain 4; Belongs to the HMGN family	POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family	0.536
HMGN4	SAR1B	ENSP00000366798	ENSP00000385432	High mobility group nucleosomal binding domain 4; Belongs to the HMGN family	GTP-binding protein SAR1b; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex; ARF GTPase family	0.486
HMGN4	SCMH1	ENSP00000366798	ENSP00000318094	High mobility group nucleosomal binding domain 4; Belongs to the HMGN family	Polycomb protein SCMH1; Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes; Belongs to the SCM family	0.468
HMGN4	SMCHD1	ENSP00000366798	ENSP00000326603	High mobility group nucleosomal binding domain 4; Belongs to the HMGN family	Structural maintenance of chromosomes flexible hinge domain-containing protein 1; Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X. Involved in a pathway that mediates the methylation of a subset of CpG islands slowly and requires the methyltransferase DNMT3B (By similarity). Required for DUX4 silencing in somatic cells	0.475
HMGN4	TWIST1	ENSP00000366798	ENSP00000242261	High mobility group nucleosomal binding domain 4; Belongs to the HMGN family	Twist-related protein 1; Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN w [...]	0.730
HMGN4	WAS	ENSP00000366798	ENSP00000365891	High mobility group nucleosomal binding domain 4; Belongs to the HMGN family	Wiskott-Aldrich syndrome protein; Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria; Wiskott-Aldrich Syndrome protein family	0.477
HMGN4	WDR26	ENSP00000366798	ENSP00000408108	High mobility group nucleosomal binding domain 4; Belongs to the HMGN family	WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta-gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. [...]	0.556
NHS	HMGN4	ENSP00000369400	ENSP00000366798	Nance-Horan syndrome protein; May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development; Belongs to the NHS family	High mobility group nucleosomal binding domain 4; Belongs to the HMGN family	0.522
POM121L2	HMGN4	ENSP00000392726	ENSP00000366798	POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family	High mobility group nucleosomal binding domain 4; Belongs to the HMGN family	0.536
SAR1B	C9orf64	ENSP00000385432	ENSP00000365522	GTP-binding protein SAR1b; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex; ARF GTPase family	Queuosine salvage protein; Involved in salvaging queuosine	0.519
SAR1B	HMGN4	ENSP00000385432	ENSP00000366798	GTP-binding protein SAR1b; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex; ARF GTPase family	High mobility group nucleosomal binding domain 4; Belongs to the HMGN family	0.486
SAR1B	WDR26	ENSP00000385432	ENSP00000408108	GTP-binding protein SAR1b; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex; ARF GTPase family	WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta-gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. [...]	0.404
SCMH1	HMGN4	ENSP00000318094	ENSP00000366798	Polycomb protein SCMH1; Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes; Belongs to the SCM family	High mobility group nucleosomal binding domain 4; Belongs to the HMGN family	0.468

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