| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARL5B | CACNB2 | ENSP00000366487 | ENSP00000320025 | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP; ARF GTPase family | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | 0.655 |
| ARL5B | CUBN | ENSP00000366487 | ENSP00000367064 | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP; ARF GTPase family | Cubilin; Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. [...] | 0.590 |
| ARL5B | ENSG00000271786 | ENSP00000366487 | ENSP00000476221 | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP; ARF GTPase family | Uncharacterized protein | 0.543 |
| ARL5B | FYCO1 | ENSP00000366487 | ENSP00000296137 | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP; ARF GTPase family | FYVE and coiled-coil domain-containing protein 1; May mediate microtubule plus end-directed vesicle transport; GOLD domain containing | 0.551 |
| ARL5B | MEF2BNB | ENSP00000366487 | ENSP00000425864 | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP; ARF GTPase family | BLOC-1-related complex subunit 8; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor | 0.589 |
| ARL5B | NSUN6 | ENSP00000366487 | ENSP00000366519 | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP; ARF GTPase family | Putative methyltransferase NSUN6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity; NOP2/Sun RNA methyltransferase family | 0.645 |
| ARL5B | PLEKHM2 | ENSP00000366487 | ENSP00000364956 | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP; ARF GTPase family | Pleckstrin homology domain-containing family M member 2; May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation. May play a role in lysosomes movement and localization at the cell periphery; Pleckstrin homology domain containing | 0.602 |
| ARL5B | RAB36 | ENSP00000366487 | ENSP00000263116 | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP; ARF GTPase family | Ras-related protein Rab-36; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family | 0.647 |
| ARL5B | TBC1D23 | ENSP00000366487 | ENSP00000377700 | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP; ARF GTPase family | TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but inste [...] | 0.725 |
| ARL5B | VPS54 | ENSP00000366487 | ENSP00000272322 | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP; ARF GTPase family | Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling; Belongs to the VPS54 family | 0.544 |
| CACNB2 | ARL5B | ENSP00000320025 | ENSP00000366487 | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP; ARF GTPase family | 0.655 |
| CACNB2 | CUBN | ENSP00000320025 | ENSP00000367064 | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | Cubilin; Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. [...] | 0.462 |
| CACNB2 | ENSG00000271786 | ENSP00000320025 | ENSP00000476221 | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | Uncharacterized protein | 0.504 |
| CACNB2 | MEF2BNB | ENSP00000320025 | ENSP00000425864 | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | BLOC-1-related complex subunit 8; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor | 0.482 |
| CACNB2 | NSUN6 | ENSP00000320025 | ENSP00000366519 | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | Putative methyltransferase NSUN6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity; NOP2/Sun RNA methyltransferase family | 0.567 |
| CUBN | ARL5B | ENSP00000367064 | ENSP00000366487 | Cubilin; Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. [...] | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP; ARF GTPase family | 0.590 |
| CUBN | CACNB2 | ENSP00000367064 | ENSP00000320025 | Cubilin; Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. [...] | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | 0.462 |
| CUBN | ENSG00000271786 | ENSP00000367064 | ENSP00000476221 | Cubilin; Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. [...] | Uncharacterized protein | 0.501 |
| CUBN | NSUN6 | ENSP00000367064 | ENSP00000366519 | Cubilin; Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. [...] | Putative methyltransferase NSUN6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity; NOP2/Sun RNA methyltransferase family | 0.555 |
| ENSG00000271786 | ARL5B | ENSP00000476221 | ENSP00000366487 | Uncharacterized protein | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP; ARF GTPase family | 0.543 |
