PLXDC2 protein (human) - STRING database

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PLXDC2

Plexin domain-containing protein 2; May play a role in tumor angiogenesis; Belongs to the plexin family (529 aa)

Predicted Functional Partners:

TMTC2

0.758

KIAA1217

0.693

CGRRF1

0.653

LASP1

0.647

FRMD4A

0.638

RNF38

0.620

ARHGAP21

0.589

ARHGAP4

0.571

MLLT6

0.564

ETNK2

0.562

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP21	KIAA1217	ENSP00000379709	ENSP00000365637	Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions; PDZ domain containing	Sickle tail protein homolog; Required for normal development of intervertebral disks	0.627
ARHGAP21	LASP1	ENSP00000379709	ENSP00000325240	Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions; PDZ domain containing	LIM and SH3 domain protein 1; Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity); LIM domain containing	0.559
ARHGAP21	MLLT6	ENSP00000379709	ENSP00000479910	Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions; PDZ domain containing	Protein AF-17; MLLT6, PHD finger containing	0.448
ARHGAP21	PLXDC2	ENSP00000379709	ENSP00000366460	Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions; PDZ domain containing	Plexin domain-containing protein 2; May play a role in tumor angiogenesis; Belongs to the plexin family	0.589
ARHGAP4	KIAA1217	ENSP00000359045	ENSP00000365637	Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells; F-BAR domain containing	Sickle tail protein homolog; Required for normal development of intervertebral disks	0.567
ARHGAP4	LASP1	ENSP00000359045	ENSP00000325240	Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells; F-BAR domain containing	LIM and SH3 domain protein 1; Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity); LIM domain containing	0.480
ARHGAP4	MLLT6	ENSP00000359045	ENSP00000479910	Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells; F-BAR domain containing	Protein AF-17; MLLT6, PHD finger containing	0.456
ARHGAP4	PLXDC2	ENSP00000359045	ENSP00000366460	Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells; F-BAR domain containing	Plexin domain-containing protein 2; May play a role in tumor angiogenesis; Belongs to the plexin family	0.571
CGRRF1	PLXDC2	ENSP00000216420	ENSP00000366460	Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins	Plexin domain-containing protein 2; May play a role in tumor angiogenesis; Belongs to the plexin family	0.653
ETNK2	PLXDC2	ENSP00000356169	ENSP00000366460	Ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity); Belongs to the choline/ethanolamine kinase family	Plexin domain-containing protein 2; May play a role in tumor angiogenesis; Belongs to the plexin family	0.562
FRMD4A	PLXDC2	ENSP00000350032	ENSP00000366460	FERM domain-containing protein 4A; Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling; FERM domain containing	Plexin domain-containing protein 2; May play a role in tumor angiogenesis; Belongs to the plexin family	0.638
KIAA1217	ARHGAP21	ENSP00000365637	ENSP00000379709	Sickle tail protein homolog; Required for normal development of intervertebral disks	Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions; PDZ domain containing	0.627
KIAA1217	ARHGAP4	ENSP00000365637	ENSP00000359045	Sickle tail protein homolog; Required for normal development of intervertebral disks	Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells; F-BAR domain containing	0.567
KIAA1217	LASP1	ENSP00000365637	ENSP00000325240	Sickle tail protein homolog; Required for normal development of intervertebral disks	LIM and SH3 domain protein 1; Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity); LIM domain containing	0.610
KIAA1217	MLLT6	ENSP00000365637	ENSP00000479910	Sickle tail protein homolog; Required for normal development of intervertebral disks	Protein AF-17; MLLT6, PHD finger containing	0.543
KIAA1217	PLXDC2	ENSP00000365637	ENSP00000366460	Sickle tail protein homolog; Required for normal development of intervertebral disks	Plexin domain-containing protein 2; May play a role in tumor angiogenesis; Belongs to the plexin family	0.693
LASP1	ARHGAP21	ENSP00000325240	ENSP00000379709	LIM and SH3 domain protein 1; Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity); LIM domain containing	Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions; PDZ domain containing	0.559
LASP1	ARHGAP4	ENSP00000325240	ENSP00000359045	LIM and SH3 domain protein 1; Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity); LIM domain containing	Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells; F-BAR domain containing	0.480
LASP1	KIAA1217	ENSP00000325240	ENSP00000365637	LIM and SH3 domain protein 1; Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity); LIM domain containing	Sickle tail protein homolog; Required for normal development of intervertebral disks	0.610
LASP1	MLLT6	ENSP00000325240	ENSP00000479910	LIM and SH3 domain protein 1; Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity); LIM domain containing	Protein AF-17; MLLT6, PHD finger containing	0.660

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