| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARAF | CTSV | ENSP00000290277 | ENSP00000445052 | Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily | Cathepsin L2; Cysteine protease. May have an important role in corneal physiology; Belongs to the peptidase C1 family | 0.532 |
| ARAF | TIMP1 | ENSP00000290277 | ENSP00000218388 | Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it [...] | 0.638 |
| ARAF | ZNF157 | ENSP00000290277 | ENSP00000366273 | Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily | Zinc finger protein 157; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.781 |
| CTSV | ARAF | ENSP00000445052 | ENSP00000290277 | Cathepsin L2; Cysteine protease. May have an important role in corneal physiology; Belongs to the peptidase C1 family | Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily | 0.532 |
| CTSV | TIMP1 | ENSP00000445052 | ENSP00000218388 | Cathepsin L2; Cysteine protease. May have an important role in corneal physiology; Belongs to the peptidase C1 family | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it [...] | 0.650 |
| CTSV | ZNF157 | ENSP00000445052 | ENSP00000366273 | Cathepsin L2; Cysteine protease. May have an important role in corneal physiology; Belongs to the peptidase C1 family | Zinc finger protein 157; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.654 |
| DCAF12L2 | ZNF157 | ENSP00000353128 | ENSP00000366273 | DDB1- and CUL4-associated factor 12-like protein 2; DDB1 and CUL4 associated factor 12 like 2; Belongs to the WD repeat DCAF12 family | Zinc finger protein 157; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.556 |
| PRR15L | TMEM63A | ENSP00000300557 | ENSP00000355800 | Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel | 0.563 |
| PRR15L | ZNF157 | ENSP00000300557 | ENSP00000366273 | Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family | Zinc finger protein 157; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.598 |
| RBM10 | USP11 | ENSP00000328848 | ENSP00000218348 | RNA-binding protein 10; May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins; G-patch domain containing | Ubiquitin carboxyl-terminal hydrolase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially ’Lys-6’ and ’Lys-63’-linked ubiquitin chains. Has lower activity with ’Lys-11’ and ’Lys-33’-linked ubiquitin chains, and extremely low activity with ’Lys-27’, ’Lys-29’ and ’Lys-48’- linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA break [...] | 0.732 |
| RBM10 | ZNF157 | ENSP00000328848 | ENSP00000366273 | RNA-binding protein 10; May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins; G-patch domain containing | Zinc finger protein 157; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.642 |
| TIGD3 | ZNF157 | ENSP00000308354 | ENSP00000366273 | Tigger transposable element-derived protein 3; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes | Zinc finger protein 157; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.543 |
| TIMP1 | ARAF | ENSP00000218388 | ENSP00000290277 | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it [...] | Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily | 0.638 |
| TIMP1 | CTSV | ENSP00000218388 | ENSP00000445052 | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it [...] | Cathepsin L2; Cysteine protease. May have an important role in corneal physiology; Belongs to the peptidase C1 family | 0.650 |
| TIMP1 | ZNF157 | ENSP00000218388 | ENSP00000366273 | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it [...] | Zinc finger protein 157; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.624 |
| TMEM63A | PRR15L | ENSP00000355800 | ENSP00000300557 | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel | Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family | 0.563 |
| TMEM63A | ZNF157 | ENSP00000355800 | ENSP00000366273 | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel | Zinc finger protein 157; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.593 |
| TRIM28 | ZNF157 | ENSP00000253024 | ENSP00000366273 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 157; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.909 |
| USP11 | RBM10 | ENSP00000218348 | ENSP00000328848 | Ubiquitin carboxyl-terminal hydrolase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially ’Lys-6’ and ’Lys-63’-linked ubiquitin chains. Has lower activity with ’Lys-11’ and ’Lys-33’-linked ubiquitin chains, and extremely low activity with ’Lys-27’, ’Lys-29’ and ’Lys-48’- linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA break [...] | RNA-binding protein 10; May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins; G-patch domain containing | 0.732 |
| USP11 | ZNF157 | ENSP00000218348 | ENSP00000366273 | Ubiquitin carboxyl-terminal hydrolase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially ’Lys-6’ and ’Lys-63’-linked ubiquitin chains. Has lower activity with ’Lys-11’ and ’Lys-33’-linked ubiquitin chains, and extremely low activity with ’Lys-27’, ’Lys-29’ and ’Lys-48’- linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA break [...] | Zinc finger protein 157; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.641 |
