| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APOOL | ARHGAP40 | ENSP00000362268 | ENSP00000362442 | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function, | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state | 0.729 |
| APOOL | CASZ1 | ENSP00000362268 | ENSP00000366221 | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function, | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | 0.596 |
| ARHGAP40 | APOOL | ENSP00000362442 | ENSP00000362268 | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function, | 0.729 |
| ARHGAP40 | CASZ1 | ENSP00000362442 | ENSP00000366221 | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | 0.647 |
| CAMTA1 | CASZ1 | ENSP00000306522 | ENSP00000366221 | Calmodulin-binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor; Belongs to the CAMTA family | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | 0.575 |
| CASZ1 | APOOL | ENSP00000366221 | ENSP00000362268 | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function, | 0.596 |
| CASZ1 | ARHGAP40 | ENSP00000366221 | ENSP00000362442 | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state | 0.647 |
| CASZ1 | CAMTA1 | ENSP00000366221 | ENSP00000306522 | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | Calmodulin-binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor; Belongs to the CAMTA family | 0.575 |
| CASZ1 | CCAR1 | ENSP00000366221 | ENSP00000265872 | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | Cell division cycle and apoptosis regulator protein 1; Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apopto [...] | 0.548 |
| CASZ1 | CLDN23 | ENSP00000366221 | ENSP00000428780 | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | Claudin-23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins | 0.647 |
| CASZ1 | EGFL7 | ENSP00000366221 | ENSP00000360764 | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | Epidermal growth factor-like protein 7; Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis | 0.738 |
| CASZ1 | EZH2 | ENSP00000366221 | ENSP00000320147 | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates ’Lys-9’ (H3K9me) and ’Lys- 27’ (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate ’Lys-27’ of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is [...] | 0.548 |
| CASZ1 | IKZF1 | ENSP00000366221 | ENSP00000331614 | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | DNA-binding protein Ikaros; Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta- globin locus [...] | 0.586 |
| CASZ1 | LRG1 | ENSP00000366221 | ENSP00000302621 | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | Leucine rich alpha-2-glycoprotein 1 | 0.681 |
| CASZ1 | ZFP1 | ENSP00000366221 | ENSP00000377080 | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | Zinc finger protein 1 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.907 |
| CCAR1 | CASZ1 | ENSP00000265872 | ENSP00000366221 | Cell division cycle and apoptosis regulator protein 1; Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apopto [...] | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | 0.548 |
| CLDN23 | CASZ1 | ENSP00000428780 | ENSP00000366221 | Claudin-23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | 0.647 |
| EGFL7 | CASZ1 | ENSP00000360764 | ENSP00000366221 | Epidermal growth factor-like protein 7; Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | 0.738 |
| EZH2 | CASZ1 | ENSP00000320147 | ENSP00000366221 | Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates ’Lys-9’ (H3K9me) and ’Lys- 27’ (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate ’Lys-27’ of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is [...] | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | 0.548 |
| EZH2 | IKZF1 | ENSP00000320147 | ENSP00000331614 | Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates ’Lys-9’ (H3K9me) and ’Lys- 27’ (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate ’Lys-27’ of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is [...] | DNA-binding protein Ikaros; Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta- globin locus [...] | 0.545 |
