DNAJC1 protein (human) - STRING database

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Score

DNAJC1

DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins (554 aa)

Predicted Functional Partners:

GIG25

0.961

AACT

0.940

HSPA8

0.929

HSPA9

0.923

HSPA5

0.910

SEC63

0.819

HSPA12A

0.774

DNAJC12

0.731

HSPA4

0.685

DNAJC6

0.678

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AACT	DNAJC1	ENSP00000450540	ENSP00000366179	Alpha-1-antichymotrypsin; Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2; Serpin peptidase inhibitors	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	0.940
AACT	GIG25	ENSP00000450540	ENSP00000376793	Alpha-1-antichymotrypsin; Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2; Serpin peptidase inhibitors	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2; Serpin peptidase inhibitors	0.802
DNAJC1	AACT	ENSP00000366179	ENSP00000450540	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	Alpha-1-antichymotrypsin; Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2; Serpin peptidase inhibitors	0.940
DNAJC1	DNAJC12	ENSP00000366179	ENSP00000225171	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	DnaJ heat shock protein family member C12	0.731
DNAJC1	DNAJC6	ENSP00000366179	ENSP00000360108	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing	0.678
DNAJC1	GIG25	ENSP00000366179	ENSP00000376793	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2; Serpin peptidase inhibitors	0.961
DNAJC1	HSPA12A	ENSP00000366179	ENSP00000358211	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	Heat shock protein family A member 12A	0.774
DNAJC1	HSPA4	ENSP00000366179	ENSP00000302961	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family	0.685
DNAJC1	HSPA5	ENSP00000366179	ENSP00000324173	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	78 kDa glucose-regulated protein; Plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (By similarity); Belongs to the heat shock protein 70 family	0.910
DNAJC1	HSPA8	ENSP00000366179	ENSP00000432083	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...]	0.929
DNAJC1	HSPA9	ENSP00000366179	ENSP00000297185	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging (By similarity); Belongs to the heat shock protein 70 family	0.923
DNAJC1	SEC63	ENSP00000366179	ENSP00000357998	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	Translocation protein SEC63 homolog; Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane; DNAJ heat shock proteins	0.819
DNAJC12	DNAJC1	ENSP00000225171	ENSP00000366179	DnaJ heat shock protein family member C12	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	0.731
DNAJC12	DNAJC6	ENSP00000225171	ENSP00000360108	DnaJ heat shock protein family member C12	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing	0.643
DNAJC12	HSPA12A	ENSP00000225171	ENSP00000358211	DnaJ heat shock protein family member C12	Heat shock protein family A member 12A	0.530
DNAJC12	HSPA4	ENSP00000225171	ENSP00000302961	DnaJ heat shock protein family member C12	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family	0.551
DNAJC12	SEC63	ENSP00000225171	ENSP00000357998	DnaJ heat shock protein family member C12	Translocation protein SEC63 homolog; Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane; DNAJ heat shock proteins	0.443
DNAJC6	DNAJC1	ENSP00000360108	ENSP00000366179	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing	DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins	0.678
DNAJC6	DNAJC12	ENSP00000360108	ENSP00000225171	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing	DnaJ heat shock protein family member C12	0.643
DNAJC6	HSPA12A	ENSP00000360108	ENSP00000358211	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing	Heat shock protein family A member 12A	0.815

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