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  • 11.0 [archived version]
STRINGSTRING
CDH22 CDH22 GZF1 GZF1 CST7 CST7 NXT1 NXT1 ACSS1 ACSS1 CST9L CST9L NT5DC2 NT5DC2 FAM163A FAM163A SPSB2 SPSB2 WDR60 WDR60 A2ML1 A2ML1
"CST9L" - Cystatin-9-like in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CST9LCystatin-9-like; Cystatins, type 2; Belongs to the cystatin family (147 aa)    
Predicted Functional Partners:
CST7
Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; Cystatins, type 2 (145 aa)
           
  0.768
GZF1
GDNF-inducible zinc finger protein 1; Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus- 5’-TGCGCN[TG][CA]TATA-3’). May be regulating VSX2/HOX10 expression; Belongs to the krueppel C2H2-type zinc-finger protein family (711 aa)
           
  0.725
NXT1
NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (140 aa)
           
  0.678
ACSS1
Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family (689 aa)
           
  0.586
FAM163A
Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family (167 aa)
           
  0.571
NT5DC2
5’-nucleotidase domain containing 2 (557 aa)
           
  0.510
SPSB2
SPRY domain-containing SOCS box protein 2; Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (263 aa)
           
  0.463
CDH22
Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity) (828 aa)
           
  0.450
WDR60
WD repeat-containing protein 60; May play a role in ciliogenesis; WD repeat domain containing (1066 aa)
           
  0.446
A2ML1
Alpha-2-macroglobulin-like protein 1; Is able to inhibit all four classes of proteinases by a unique ’trapping’ mechanism. This protein has a peptide stretch, called the ’bait region’ which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and [...] (1454 aa)
           
  0.420
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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