node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A2ML1 | CST9L | ENSP00000299698 | ENSP00000366178 | Alpha-2-macroglobulin-like protein 1; Is able to inhibit all four classes of proteinases by a unique ’trapping’ mechanism. This protein has a peptide stretch, called the ’bait region’ which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and [...] | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | 0.420 |
A2ML1 | FAM163A | ENSP00000299698 | ENSP00000354891 | Alpha-2-macroglobulin-like protein 1; Is able to inhibit all four classes of proteinases by a unique ’trapping’ mechanism. This protein has a peptide stretch, called the ’bait region’ which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and [...] | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family | 0.414 |
ACSS1 | CST7 | ENSP00000316924 | ENSP00000420384 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; Cystatins, type 2 | 0.660 |
ACSS1 | CST9L | ENSP00000316924 | ENSP00000366178 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | 0.586 |
ACSS1 | GZF1 | ENSP00000316924 | ENSP00000338290 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | GDNF-inducible zinc finger protein 1; Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus- 5’-TGCGCN[TG][CA]TATA-3’). May be regulating VSX2/HOX10 expression; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.701 |
ACSS1 | NXT1 | ENSP00000316924 | ENSP00000254998 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 | 0.653 |
CDH22 | CST9L | ENSP00000437790 | ENSP00000366178 | Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity) | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | 0.450 |
CST7 | ACSS1 | ENSP00000420384 | ENSP00000316924 | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; Cystatins, type 2 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | 0.660 |
CST7 | CST9L | ENSP00000420384 | ENSP00000366178 | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; Cystatins, type 2 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | 0.768 |
CST7 | GZF1 | ENSP00000420384 | ENSP00000338290 | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; Cystatins, type 2 | GDNF-inducible zinc finger protein 1; Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus- 5’-TGCGCN[TG][CA]TATA-3’). May be regulating VSX2/HOX10 expression; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.691 |
CST7 | NXT1 | ENSP00000420384 | ENSP00000254998 | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; Cystatins, type 2 | NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 | 0.659 |
CST9L | A2ML1 | ENSP00000366178 | ENSP00000299698 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | Alpha-2-macroglobulin-like protein 1; Is able to inhibit all four classes of proteinases by a unique ’trapping’ mechanism. This protein has a peptide stretch, called the ’bait region’ which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and [...] | 0.420 |
CST9L | ACSS1 | ENSP00000366178 | ENSP00000316924 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | 0.586 |
CST9L | CDH22 | ENSP00000366178 | ENSP00000437790 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity) | 0.450 |
CST9L | CST7 | ENSP00000366178 | ENSP00000420384 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; Cystatins, type 2 | 0.768 |
CST9L | FAM163A | ENSP00000366178 | ENSP00000354891 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family | 0.571 |
CST9L | GZF1 | ENSP00000366178 | ENSP00000338290 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | GDNF-inducible zinc finger protein 1; Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus- 5’-TGCGCN[TG][CA]TATA-3’). May be regulating VSX2/HOX10 expression; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.725 |
CST9L | NT5DC2 | ENSP00000366178 | ENSP00000406933 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | 5’-nucleotidase domain containing 2 | 0.510 |
CST9L | NXT1 | ENSP00000366178 | ENSP00000254998 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 | 0.678 |
CST9L | SPSB2 | ENSP00000366178 | ENSP00000428338 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | SPRY domain-containing SOCS box protein 2; Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | 0.463 |