GPR180 protein (human) - STRING database

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GPR180

Integral membrane protein GPR180; G protein-coupled receptor 180 (440 aa)

Predicted Functional Partners:

SETMAR

0.907

TGDS

0.757

PPP1R12C

0.669

PRPF19

0.645

RPS9

0.605

PEX5L

0.585

SGCA

0.577

CHML

0.555

ETF1

0.539

GPR176

0.530

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHML	GPR180	ENSP00000355511	ENSP00000366157	Rab proteins geranylgeranyltransferase component A 2; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family	Integral membrane protein GPR180; G protein-coupled receptor 180	0.555
ETF1	GPR180	ENSP00000353741	ENSP00000366157	Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons	Integral membrane protein GPR180; G protein-coupled receptor 180	0.539
ETF1	RPS9	ENSP00000353741	ENSP00000302896	Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons	Ribosomal protein S9	0.998
GPR176	GPR180	ENSP00000453076	ENSP00000366157	G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production	Integral membrane protein GPR180; G protein-coupled receptor 180	0.530
GPR180	CHML	ENSP00000366157	ENSP00000355511	Integral membrane protein GPR180; G protein-coupled receptor 180	Rab proteins geranylgeranyltransferase component A 2; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family	0.555
GPR180	ETF1	ENSP00000366157	ENSP00000353741	Integral membrane protein GPR180; G protein-coupled receptor 180	Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons	0.539
GPR180	GPR176	ENSP00000366157	ENSP00000453076	Integral membrane protein GPR180; G protein-coupled receptor 180	G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production	0.530
GPR180	PEX5L	ENSP00000366157	ENSP00000419975	Integral membrane protein GPR180; G protein-coupled receptor 180	PEX5-related protein; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence; Belongs to the peroxisomal targeting signal receptor family	0.585
GPR180	PPP1R12C	ENSP00000366157	ENSP00000263433	Integral membrane protein GPR180; G protein-coupled receptor 180	Protein phosphatase 1 regulatory subunit 12C; Regulates myosin phosphatase activity; Ankyrin repeat domain containing	0.669
GPR180	PRPF19	ENSP00000366157	ENSP00000227524	Integral membrane protein GPR180; G protein-coupled receptor 180	Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates ’Lys-63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruite [...]	0.645
GPR180	RPS9	ENSP00000366157	ENSP00000302896	Integral membrane protein GPR180; G protein-coupled receptor 180	Ribosomal protein S9	0.605
GPR180	SETMAR	ENSP00000366157	ENSP00000373354	Integral membrane protein GPR180; G protein-coupled receptor 180	Histone-lysine N-methyltransferase SETMAR; Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5’-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. In parallel, has a histone methyltransfe [...]	0.907
GPR180	SGCA	ENSP00000366157	ENSP00000262018	Integral membrane protein GPR180; G protein-coupled receptor 180	Alpha-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix	0.577
GPR180	TGDS	ENSP00000366157	ENSP00000261296	Integral membrane protein GPR180; G protein-coupled receptor 180	dTDP-D-glucose 4,6-dehydratase; Short chain dehydrogenase/reductase superfamily	0.757
PEX5L	GPR180	ENSP00000419975	ENSP00000366157	PEX5-related protein; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence; Belongs to the peroxisomal targeting signal receptor family	Integral membrane protein GPR180; G protein-coupled receptor 180	0.585
PPP1R12C	GPR180	ENSP00000263433	ENSP00000366157	Protein phosphatase 1 regulatory subunit 12C; Regulates myosin phosphatase activity; Ankyrin repeat domain containing	Integral membrane protein GPR180; G protein-coupled receptor 180	0.669
PRPF19	GPR180	ENSP00000227524	ENSP00000366157	Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates ’Lys-63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruite [...]	Integral membrane protein GPR180; G protein-coupled receptor 180	0.645
PRPF19	SETMAR	ENSP00000227524	ENSP00000373354	Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates ’Lys-63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruite [...]	Histone-lysine N-methyltransferase SETMAR; Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5’-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. In parallel, has a histone methyltransfe [...]	0.987
RPS9	ETF1	ENSP00000302896	ENSP00000353741	Ribosomal protein S9	Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons	0.998
RPS9	GPR180	ENSP00000302896	ENSP00000366157	Ribosomal protein S9	Integral membrane protein GPR180; G protein-coupled receptor 180	0.605

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