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  • 11.0 [archived version]
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ZNF385B ZNF385B ARHGEF6 ARHGEF6 SPACA5 SPACA5 SPACA5B SPACA5B ZNF81 ZNF81 TRIM28 TRIM28 KDM5C KDM5C PHF6 PHF6 TBC1D25 TBC1D25 TIMP1 TIMP1 ARAF ARAF
"ZNF81" - Zinc finger protein 81 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ZNF81Zinc finger protein 81; May be involved in transcriptional regulation; X-linked mental retardation (661 aa)    
Predicted Functional Partners:
ZNF385B
Zinc finger protein 385B; May play a role in p53/TP53-mediated apoptosis (471 aa)
           
  0.803
ARAF
Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily (609 aa)
     
 
  0.726
TBC1D25
TBC1 domain family member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes (688 aa)
     
 
  0.650
PHF6
PHD finger protein 6; Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription; PHD finger proteins (365 aa)
     
 
  0.619
SPACA5B
Sperm acrosome associated 5B; Lysozymes, c-type (159 aa)
           
  0.553
KDM5C
Lysine-specific demethylase 5C; Histone demethylase that specifically demethylates ’Lys- 4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’, H3 ’Lys-27’, H3 ’Lys-36’, H3 ’Lys-79’ or H4 ’Lys-20’. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-4’. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer- mediated transcriptional activation of the core clock component PER2 (By [...] (1560 aa)
       
 
  0.552
SPACA5
Sperm acrosome associated 5; Belongs to the glycosyl hydrolase 22 family (159 aa)
           
  0.543
ARHGEF6
Rho guanine nucleotide exchange factor 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF); Pleckstrin homology domain containing (776 aa)
           
  0.536
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
 
  0.524
TIMP1
Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it [...] (207 aa)
           
  0.502
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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